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Page 1
Renadirsen, a Novel 2'OMeRNA/ENA® Chimera Antisense Oligonucleotide, Induces Robust Exon 45 Skipping for Dystrophin In Vivo.
Ito K, Takakusa H, Kakuta M, Kanda A, Takagi N, Nagase H, Watanabe N, Asano D, Goda R, Masuda T, Nakamura A, Onishi Y, Onoda T, Koizumi M, Takeshima Y, Matsuo M, Takaishi K. Ito K, et al. Among authors: onishi y. Curr Issues Mol Biol. 2021 Sep 25;43(3):1267-1281. doi: 10.3390/cimb43030090. Curr Issues Mol Biol. 2021. PMID: 34698059 Free PMC article.
An improved synthesis of 2'-O,4'-C-ethylene nucleic acid (ENA) and thermodynamic studies of duplex formation containing the guanosine ENA unit.
Takagi-Sato M, Morita K, Onishi Y, Watahiki Y, Ishigaki T, Akita T, Tomita E, Kawakami J, Koizumi M. Takagi-Sato M, et al. Among authors: onishi y. Nucleosides Nucleotides Nucleic Acids. 2020;39(6):838-852. doi: 10.1080/15257770.2019.1708389. Epub 2020 Jan 30. Nucleosides Nucleotides Nucleic Acids. 2020. PMID: 31997701
Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5.
Yamamura T, Horinouchi T, Adachi T, Terakawa M, Takaoka Y, Omachi K, Takasato M, Takaishi K, Shoji T, Onishi Y, Kanazawa Y, Koizumi M, Tomono Y, Sugano A, Shono A, Minamikawa S, Nagano C, Sakakibara N, Ishiko S, Aoto Y, Kamura M, Harita Y, Miura K, Kanda S, Morisada N, Rossanti R, Ye MJ, Nozu Y, Matsuo M, Kai H, Iijima K, Nozu K. Yamamura T, et al. Among authors: onishi y. Nat Commun. 2020 Jun 2;11(1):2777. doi: 10.1038/s41467-020-16605-x. Nat Commun. 2020. PMID: 32488001 Free PMC article.
Not all 2',4'-bridged modifications stabilize DNA/RNA duplexes.
Akita T, Tomita-Sudo E, Itoh S, Sakimoto N, Masuda T, Nakamura A, Onishi Y, Koizumi M, Kawakami J. Akita T, et al. Among authors: onishi y. Nucleosides Nucleotides Nucleic Acids. 2024;43(1):57-64. doi: 10.1080/15257770.2023.2232414. Epub 2023 Jul 9. Nucleosides Nucleotides Nucleic Acids. 2024. PMID: 37424260
A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T.
Ito K, Tajima G, Kamisato C, Tsumura M, Iwamoto M, Sekiguchi Y, Numata Y, Watanabe K, Yabe Y, Kanki S, Fujieda Y, Goto K, Sogawa Y, Oitate M, Nagase H, Tsuji S, Nishizawa T, Kakuta M, Masuda T, Onishi Y, Koizumi M, Nakamura H, Okada S, Matsuo M, Takaishi K. Ito K, et al. Among authors: onishi y. J Clin Invest. 2023 Dec 1;133(23):e163464. doi: 10.1172/JCI163464. J Clin Invest. 2023. PMID: 37788110 Free PMC article.
Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: onishi y. Bioorg Med Chem. 2018 Oct 1;26(18):5099-5117. doi: 10.1016/j.bmc.2018.09.005. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30220602
Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: onishi y. Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098. doi: 10.1016/j.bmc.2018.09.006. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30241907
Alkylsulfanyl analogs as potent α2δ ligands.
Shimada K, Ohata Y, Kobayashi J, Onishi Y, Kawamura A, Domon Y, Arakawa N, Inoue T, Kitano Y, Matsuda F, Abe Y, Deguchi T. Shimada K, et al. Among authors: onishi y. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2000-2002. doi: 10.1016/j.bmcl.2018.05.006. Epub 2018 May 4. Bioorg Med Chem Lett. 2018. PMID: 29752183
1,063 results