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Antibacterial activity of novel dual bacterial DNA type II topoisomerase inhibitors.
D'Atanasio N, Capezzone de Joannon A, Di Sante L, Mangano G, Ombrato R, Vitiello M, Bartella C, Magarò G, Prati F, Milanese C, Vignaroli C, Di Giorgio FP, Tongiani S. D'Atanasio N, et al. Among authors: ombrato r. PLoS One. 2020 Feb 19;15(2):e0228509. doi: 10.1371/journal.pone.0228509. eCollection 2020. PLoS One. 2020. PMID: 32074119 Free PMC article.
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.
Magarò G, Prati F, Garofalo B, Corso G, Furlotti G, Apicella C, Mangano G, D'Atanasio N, Robinson D, Di Giorgio FP, Ombrato R. Magarò G, et al. Among authors: ombrato r. J Med Chem. 2019 Aug 22;62(16):7445-7472. doi: 10.1021/acs.jmedchem.9b00394. Epub 2019 Jul 31. J Med Chem. 2019. PMID: 31276392
Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands.
Furlotti G, Alisi MA, Apicella C, Capezzone de Joannon A, Cazzolla N, Costi R, Cuzzucoli Crucitti G, Garrone B, Iacovo A, Magarò G, Mangano G, Miele G, Ombrato R, Pescatori L, Polenzani L, Rosi F, Vitiello M, Di Santo R. Furlotti G, et al. Among authors: ombrato r. J Med Chem. 2012 Nov 26;55(22):9446-66. doi: 10.1021/jm300573d. Epub 2012 Oct 24. J Med Chem. 2012. PMID: 23043420
Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders.
Furlotti G, Alisi MA, Cazzolla N, Dragone P, Durando L, Magarò G, Mancini F, Mangano G, Ombrato R, Vitiello M, Armirotti A, Capurro V, Lanfranco M, Ottonello G, Summa M, Reggiani A. Furlotti G, et al. Among authors: ombrato r. J Med Chem. 2015 Nov 25;58(22):8920-37. doi: 10.1021/acs.jmedchem.5b01208. Epub 2015 Nov 13. J Med Chem. 2015. PMID: 26486317
Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and In Vivo Activity in a Mood Disorder Model.
Prati F, Buonfiglio R, Furlotti G, Cavarischia C, Mangano G, Picollo R, Oggianu L, di Matteo A, Olivieri S, Bovi G, Porceddu PF, Reggiani A, Garrone B, Di Giorgio FP, Ombrato R. Prati F, et al. Among authors: ombrato r. ACS Med Chem Lett. 2020 Mar 24;11(5):825-831. doi: 10.1021/acsmedchemlett.9b00633. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435391 Free PMC article.
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