Olker JH - Search Results

1

Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases.

Olker JH, Korte JJ, Denny JS, Hartig PC, Cardon MC, Knutsen CN, Kent PM, Christensen JP, Degitz SJ, Hornung MW. Olker JH, et al. Toxicol Sci. 2019 Apr 1;168(2):430-442. doi: 10.1093/toxsci/kfy302. Toxicol Sci. 2019. PMID: 30561685 Free PMC article.

2

Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity.

Hornung MW, Korte JJ, Olker JH, Denny JS, Knutsen C, Hartig PC, Cardon MC, Degitz SJ. Hornung MW, et al. Among authors: olker jh. Toxicol Sci. 2018 Apr 1;162(2):570-581. doi: 10.1093/toxsci/kfx279. Toxicol Sci. 2018. PMID: 29228274 Free PMC article.

3

Evaluating Iodide Recycling Inhibition as a Novel Molecular Initiating Event for Thyroid Axis Disruption in Amphibians.

Olker JH, Haselman JT, Kosian PA, Donnay KG, Korte JJ, Blanksma C, Hornung MW, Degitz SJ. Olker JH, et al. Toxicol Sci. 2018 Dec 1;166(2):318-331. doi: 10.1093/toxsci/kfy203. Toxicol Sci. 2018. PMID: 30137636 Free PMC article.

4

Targeted Pathway-based In Vivo Testing Using Thyroperoxidase Inhibition to Evaluate Plasma Thyroxine as a Surrogate Metric of Metamorphic Success in Model Amphibian Xenopus laevis.

Haselman JT, Olker JH, Kosian PA, Korte JJ, Swintek JA, Denny JS, Nichols JW, Tietge JE, Hornung MW, Degitz SJ. Haselman JT, et al. Among authors: olker jh. Toxicol Sci. 2020 Jun 1;175(2):236-250. doi: 10.1093/toxsci/kfaa036. Toxicol Sci. 2020. PMID: 32176285 Free PMC article.

5

In vitro screening for chemical inhibition of the iodide recycling enzyme, iodotyrosine deiodinase.

Olker JH, Korte JJ, Denny JS, Haselman JT, Hartig PC, Cardon MC, Hornung MW, Degitz SJ. Olker JH, et al. Toxicol In Vitro. 2021 Mar;71:105073. doi: 10.1016/j.tiv.2020.105073. Epub 2020 Dec 29. Toxicol In Vitro. 2021. PMID: 33352258 Free PMC article.

6

Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals.

Mayasich SA, Korte JJ, Denny JS, Hartig PC, Olker JH, DeGoey P, O'Flanagan J, Degitz SJ, Hornung MW. Mayasich SA, et al. Among authors: olker jh. Toxicol In Vitro. 2021 Jun;73:105141. doi: 10.1016/j.tiv.2021.105141. Epub 2021 Mar 11. Toxicol In Vitro. 2021. PMID: 33713820 Free PMC article.

7

Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus laevis Using Iopanoic Acid.

Haselman JT, Olker JH, Kosian PA, Korte JJ, Denny JS, Tietge JE, Hornung MW, Degitz SJ. Haselman JT, et al. Among authors: olker jh. Toxicol Sci. 2022 Apr 26;187(1):139-149. doi: 10.1093/toxsci/kfac014. Toxicol Sci. 2022. PMID: 35179606 Free PMC article.

8

Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase.

Olker JH, Korte JJ, Haselman JT, Hornung MW, Degitz SJ. Olker JH, et al. Aquat Toxicol. 2022 Aug;249:106227. doi: 10.1016/j.aquatox.2022.106227. Epub 2022 Jun 15. Aquat Toxicol. 2022. PMID: 35767922 Free PMC article.

9

Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment.

Schaupp CM, Maloney EM, Mattingly KZ, Olker JH, Villeneuve DL. Schaupp CM, et al. Among authors: olker jh. Toxicol Sci. 2023 Sep 28;195(2):145-154. doi: 10.1093/toxsci/kfad072. Toxicol Sci. 2023. PMID: 37490521

10

Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo.

Eytcheson SA, Olker JH, Friedman KP, Hornung MW, Degitz SJ. Eytcheson SA, et al. Among authors: olker jh. Regul Toxicol Pharmacol. 2023 Oct;144:105491. doi: 10.1016/j.yrtph.2023.105491. Epub 2023 Sep 4. Regul Toxicol Pharmacol. 2023. PMID: 37666444 Review.

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