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A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3.
Hackney CM, Flórez Salcedo P, Mueller E, Koch TL, Kjelgaard LD, Watkins M, Zachariassen LG, Tuelung PS, McArthur JR, Adams DJ, Kristensen AS, Olivera B, Finol-Urdaneta RK, Safavi-Hemami H, Morth JP, Ellgaard L. Hackney CM, et al. Among authors: olivera b. PLoS Biol. 2023 Aug 3;21(8):e3002217. doi: 10.1371/journal.pbio.3002217. eCollection 2023 Aug. PLoS Biol. 2023. PMID: 37535677 Free PMC article.
A toxin-based approach to neuropeptide and peptide hormone discovery.
Koch TL, Torres JP, Baskin RP, Salcedo PF, Chase K, Olivera BM, Safavi-Hemami H. Koch TL, et al. Among authors: olivera bm. Front Mol Neurosci. 2023 Aug 31;16:1176662. doi: 10.3389/fnmol.2023.1176662. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37720554 Free PMC article.
CYP1B1-derived epoxides modulate the TRPA1 channel in chronic pain.
Sun L, Zhang J, Niu C, Deering-Rice CE, Hughen RW, Lamb JG, Rose K, Chase KM, Almestica-Roberts M, Walter M, Schmidt EW, Light AR, Olivera BM, Reilly CA. Sun L, et al. Among authors: olivera bm. Acta Pharm Sin B. 2023 Jan;13(1):68-81. doi: 10.1016/j.apsb.2022.09.007. Epub 2022 Sep 14. Acta Pharm Sin B. 2023. PMID: 36815047 Free PMC article.
Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus.
Neves JLB, Urcino C, Chase K, Dowell C, Hone AJ, Morgenstern D, Chua VM, Ramiro IBL, Imperial JS, Leavitt LS, Phan J, Fisher FA, Watkins M, Raghuraman S, Tun JO, Ueberheide BM, McIntosh JM, Vasconcelos V, Olivera BM, Gajewiak J. Neves JLB, et al. Among authors: olivera bm. Mar Drugs. 2024 Feb 29;22(3):118. doi: 10.3390/md22030118. Mar Drugs. 2024. PMID: 38535458 Free PMC article.
Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads.
Ramiro IBL, Bjørn-Yoshimoto WE, Imperial JS, Gajewiak J, Salcedo PF, Watkins M, Taylor D, Resager W, Ueberheide B, Bräuner-Osborne H, Whitby FG, Hill CP, Martin LF, Patwardhan A, Concepcion GP, Olivera BM, Safavi-Hemami H. Ramiro IBL, et al. Among authors: olivera bm. Sci Adv. 2022 Mar 25;8(12):eabk1410. doi: 10.1126/sciadv.abk1410. Epub 2022 Mar 23. Sci Adv. 2022. PMID: 35319982 Free PMC article.
435 results