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Page 1
Structure-activity relationships of novel N-imidazoylpiperazines with potent anti-Trypanosoma cruzi activity.
Espinoza-Chávez RM, Oliveira Rezende Júnior C, de Souza ML, Pauli I, Valli M, Gomes Ferreira LL, Chelucci RC, Michelan-Duarte S, Krogh R, Romualdo da Silva FB, Cruz FC, de Oliveira AS, Andricopulo AD, Dias LC. Espinoza-Chávez RM, et al. Among authors: oliveira rezende junior c. Future Med Chem. 2024 Feb;16(3):253-269. doi: 10.4155/fmc-2023-0185. Epub 2024 Jan 9. Future Med Chem. 2024. PMID: 38193294
Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors.
Maltarollo VG, da Silva EB, Kronenberger T, Sena Andrade MM, de Lima Marques GV, Cândido Oliveira NJ, Santos LH, Oliveira Rezende Júnior C, Cassiano Martinho AC, Skinner D, Fajtová P, M Fernandes TH, Silveira Dos Santos ED, Rodrigues Gazolla PA, Martins de Souza AP, da Silva ML, Dos Santos FS, Lavorato SN, Oliveira Bretas AC, Carvalho DT, Franco LL, Luedtke S, Giardini MA, Poso A, Dias LC, Podust LM, Alves RJ, McKerrow J, Andrade SF, Teixeira RR, Siqueira-Neto JL, O'Donoghue A, de Oliveira RB, Ferreira RS. Maltarollo VG, et al. Among authors: oliveira rezende junior c. Future Med Chem. 2023 Jun;15(11):959-985. doi: 10.4155/fmc-2023-0034. Epub 2023 Jul 12. Future Med Chem. 2023. PMID: 37435731
New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi, the causative agent of Chagas disease.
Murta SMF, Lemos Santana PA, Jacques Dit Lapierre TJW, Penteado AB, El Hajje M, Navarro Vinha TC, Liarte DB, de Souza ML, Goulart Trossini GH, de Oliveira Rezende Júnior C, de Oliveira RB, Ferreira RS. Murta SMF, et al. Among authors: de oliveira rezende junior c. Expert Opin Drug Discov. 2024 May 7:1-13. doi: 10.1080/17460441.2024.2349155. Online ahead of print. Expert Opin Drug Discov. 2024. PMID: 38715393 Review.
Optimization of benzenesulfonyl derivatives as anti-Trypanosomatidae agents: Structural design, synthesis, and pharmacological assessment against Trypanosoma cruzi and Leishmania infantum.
Freitas de Lima Hercos G, Gabriela Faleiro de Moura Lodi Cruz M, Clara Cassiano Martinho A, de Melo Resende D, Farago Nascimento D, Derksen Macruz P, Jorge Pilau E, Maria Fonseca Murta S, de Oliveira Rezende Júnior C. Freitas de Lima Hercos G, et al. Among authors: de oliveira rezende junior c. Bioorg Med Chem. 2024 May 1;105:117736. doi: 10.1016/j.bmc.2024.117736. Epub 2024 Apr 24. Bioorg Med Chem. 2024. PMID: 38677111
Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum.
Lapierre TJWJD, Farago DN, de Moura Lodi Cruz MGF, de Melo Resende D, de Oliveira ACR, Dos Santos BRM, de Oliveira Souza F, Michelan-Duarte S, Chelucci RC, Andricopulo AD, Ferreira LLG, Pilau EJ, Murta SMF, de Oliveira Rezende Júnior C. Lapierre TJWJD, et al. Among authors: de oliveira rezende junior c. Chem Biol Drug Des. 2024 Apr;103(4):e14525. doi: 10.1111/cbdd.14525. Chem Biol Drug Des. 2024. PMID: 38627214
Discovery and structural optimization of a new series of N-acyl-2-aminobenzothiazole as inhibitors of Zika virus.
Dias RFC, Ribeiro BMRM, Cassani NM, Farago DN, Antoniucci GA, de Oliveira Rocha RE, de Oliveira Souza F, Pilau EJ, Jardim ACG, Ferreira RS, de Oliveira Rezende Júnior C. Dias RFC, et al. Among authors: de oliveira rezende junior c. Bioorg Med Chem. 2023 Nov 15;95:117488. doi: 10.1016/j.bmc.2023.117488. Epub 2023 Oct 5. Bioorg Med Chem. 2023. PMID: 37812885
Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease.
de Oliveira Rezende Júnior C, Martinez PDG, Ferreira RAA, Koovits PJ, Miranda Soares B, Ferreira LLG, Michelan-Duarte S, Chelucci RC, Andricopulo AD, Matheeussen A, Van Pelt N, Caljon G, Maes L, Campbell S, Kratz JM, Mowbray CE, Dias LC. de Oliveira Rezende Júnior C, et al. Eur J Med Chem. 2023 Jan 15;246:114925. doi: 10.1016/j.ejmech.2022.114925. Epub 2022 Nov 15. Eur J Med Chem. 2023. PMID: 36459758 Free article.
Synthesis, Design, and Structure-Activity Relationship of a Benzenesulfonylpiperazine Series against Trypanosoma cruzi.
Cassiano Martinho AC, de Melo Resende D, Landin ES, Dit Lapierre TJWJ, Bernardes TCD, Martins LC, Ferreira RS, Murta SMF, de Oliveira Rezende Júnior C. Cassiano Martinho AC, et al. Among authors: de oliveira rezende junior c. ChemMedChem. 2022 Oct 6;17(19):e202200211. doi: 10.1002/cmdc.202200211. Epub 2022 Sep 6. ChemMedChem. 2022. PMID: 35993440
Chemoinformatics Studies on a Series of Imidazoles as Cruzain Inhibitors.
Medeiros AR, Ferreira LLG, de Souza ML, de Oliveira Rezende Junior C, Espinoza-Chávez RM, Dias LC, Andricopulo AD. Medeiros AR, et al. Among authors: de oliveira rezende junior c. Biomolecules. 2021 Apr 15;11(4):579. doi: 10.3390/biom11040579. Biomolecules. 2021. PMID: 33920961 Free PMC article.
Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach.
de Souza ML, de Oliveira Rezende Junior C, Ferreira RS, Espinoza Chávez RM, Ferreira LLG, Slafer BW, Magalhães LG, Krogh R, Oliva G, Cruz FC, Dias LC, Andricopulo AD. de Souza ML, et al. Among authors: de oliveira rezende junior c. J Chem Inf Model. 2020 Feb 24;60(2):1028-1041. doi: 10.1021/acs.jcim.9b00802. Epub 2019 Dec 11. J Chem Inf Model. 2020. PMID: 31765144
11 results