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Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition.
Park JE, Kirsch K, Lee H, Oliva P, Ahn JI, Ravishankar H, Zeng Y, Fox SD, Kirby SA, Badhwar P, Andresson T, Jacobson KA, Lee KS. Park JE, et al. Among authors: oliva p. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2305037120. doi: 10.1073/pnas.2305037120. Epub 2023 Aug 21. Proc Natl Acad Sci U S A. 2023. PMID: 37603740 Free PMC article.
Structure-Activity Relationship of 3-Methylcytidine-5'-α,β-methylenediphosphates as CD73 Inhibitors.
Scortichini M, Idris RM, Moschütz S, Keim A, Salmaso V, Dobelmann C, Oliva P, Losenkova K, Irjala H, Vaittinen S, Sandholm J, Yegutkin GG, Sträter N, Junker A, Müller CE, Jacobson KA. Scortichini M, et al. Among authors: oliva p. J Med Chem. 2022 Feb 10;65(3):2409-2433. doi: 10.1021/acs.jmedchem.1c01852. Epub 2022 Jan 26. J Med Chem. 2022. PMID: 35080883 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35554636
Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold.
Romagnoli R, Prencipe F, Oliva P, Cacciari B, Balzarini J, Liekens S, Hamel E, Brancale A, Ferla S, Manfredini S, Zurlo M, Finotti A, Gambari R. Romagnoli R, et al. Among authors: oliva p. Molecules. 2020 Apr 7;25(7):1690. doi: 10.3390/molecules25071690. Molecules. 2020. PMID: 32272719 Free PMC article.
Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities.
Romagnoli R, Oliva P, Prencipe F, Manfredini S, Budassi F, Brancale A, Ferla S, Hamel E, Corallo D, Aveic S, Manfreda L, Mariotto E, Bortolozzi R, Viola G. Romagnoli R, et al. Among authors: oliva p. Pharmaceuticals (Basel). 2022 Aug 21;15(8):1031. doi: 10.3390/ph15081031. Pharmaceuticals (Basel). 2022. PMID: 36015179 Free PMC article.
2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.
Romagnoli R, Kimatrai Salvador M, Schiaffino Ortega S, Baraldi PG, Oliva P, Baraldi S, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Balzarini J, Liekens S, Mattiuzzo E, Basso G, Viola G. Romagnoli R, et al. Among authors: oliva p. Eur J Med Chem. 2018 Jan 1;143:683-698. doi: 10.1016/j.ejmech.2017.11.096. Eur J Med Chem. 2018. PMID: 29220790 Free PMC article.
239 results