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Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
Malwal SR, Mazurek B, Ko J, Xie P, Barnes C, Varvitsiotis C, Zimmerman MD, Olatunji S, Lee J, Xie M, Sarathy J, Caffrey M, Strynadka NCJ, Dartois V, Dick T, Lee BNR, Russell DG, Oldfield E. Malwal SR, et al. Among authors: oldfield e. J Med Chem. 2023 Jun 8;66(11):7553-7569. doi: 10.1021/acs.jmedchem.3c00398. Epub 2023 May 26. J Med Chem. 2023. PMID: 37235809 Free PMC article.
Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).
Elsebaei MM, Mohammad H, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS. Elsebaei MM, et al. Among authors: oldfield e. Eur J Med Chem. 2018 Mar 25;148:195-209. doi: 10.1016/j.ejmech.2018.02.031. Epub 2018 Feb 12. Eur J Med Chem. 2018. PMID: 29459278 Free PMC article.
Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites.
Stampolaki M, Malwal SR, Alvarez-Cabrera N, Gao Z, Moniruzzaman M, Babii SO, Naziris N, Rey-Cibati A, Valladares-Delgado M, Turcu AL, Baek KH, Phan TN, Lee H, Alcaraz M, Watson S, van der Watt M, Coertzen D, Efstathiou N, Chountoulesi M, Shoen CM, Papanastasiou IP, Brea J, Cynamon MH, Birkholtz LM, Kremer L, No JH, Vázquez S, Benaim G, Demetzos C, Zgurskaya HI, Dick T, Oldfield E, Kolocouris AD. Stampolaki M, et al. Among authors: oldfield e. ACS Infect Dis. 2023 Feb 10;9(2):342-364. doi: 10.1021/acsinfecdis.2c00537. Epub 2023 Jan 27. ACS Infect Dis. 2023. PMID: 36706233 Free PMC article.
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.
Desai J, Wang Y Dr, Wang K Dr, Malwal SR Dr, Oldfield E. Desai J, et al. Among authors: oldfield e. ChemMedChem. 2016 Oct 6;11(19):2205-2215. doi: 10.1002/cmdc.201600343. Epub 2016 Aug 30. ChemMedChem. 2016. PMID: 27571880 Free PMC article.
927 results