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Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.
Ohe T, Umezawa R, Kitagawara Y, Yasuda D, Takahashi K, Nakamura S, Abe A, Sekine S, Ito K, Okunushi K, Morio H, Furihata T, Anzai N, Mashino T. Ohe T, et al. Among authors: okunushi k. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3708-3711. doi: 10.1016/j.bmcl.2018.10.023. Epub 2018 Oct 15. Bioorg Med Chem Lett. 2018. PMID: 30389287
Sivelestat sodium hydrate treatment for refractory Kawasaki disease.
Ebata R, Yasukawa K, Nagai K, Saito Y, Higashi K, Homma J, Takada N, Takechi F, Saito N, Kobayashi H, Okunushi K, Hamada H, Kohno Y, Hanaoka H, Shimojo N. Ebata R, et al. Among authors: okunushi k. Pediatr Int. 2019 May;61(5):438-443. doi: 10.1111/ped.13851. Epub 2019 May 17. Pediatr Int. 2019. PMID: 30916859 Clinical Trial.
Facial nerve palsy associated with atomoxetine-induced hypertension.
Kobayashi H, Fujii K, Kobayashi M, Saito N, Okunushi K, Ebata R, Shiohama T, Sawada D, Shimojo N. Kobayashi H, et al. Among authors: okunushi k. Brain Dev. 2019 Mar;41(3):310-312. doi: 10.1016/j.braindev.2018.09.009. Epub 2018 Oct 9. Brain Dev. 2019. PMID: 30314873
Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial.
Hamada H, Suzuki H, Onouchi Y, Ebata R, Terai M, Fuse S, Okajima Y, Kurotobi S, Hirai K, Soga T, Ishiguchi Y, Okuma Y, Takada N, Yanai M, Sato J, Nakayashiro M, Ayusawa M, Yamamoto E, Nomura Y, Hashimura Y, Ouchi K, Masuda H, Takatsuki S, Hirono K, Ariga T, Higaki T, Otsuki A, Terauchi M, Aoyagi R, Sato T, Fujii Y, Fujiwara T, Hanaoka H, Hata A; KAICA trial Investigators. Hamada H, et al. Lancet. 2019 Mar 16;393(10176):1128-1137. doi: 10.1016/S0140-6736(18)32003-8. Epub 2019 Mar 7. Lancet. 2019. PMID: 30853151 Clinical Trial.