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TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies.
Carideo Cunniff E, Sato Y, Mai D, Appleman VA, Iwasaki S, Kolev V, Matsuda A, Shi J, Mochizuki M, Yoshikawa M, Huang J, Shen L, Haridas S, Shinde V, Gemski C, Roberts ER, Ghasemi O, Bazzazi H, Menon S, Traore T, Shi P, Thelen TD, Conlon J, Abu-Yousif AO, Arendt C, Shaw MH, Okaniwa M. Carideo Cunniff E, et al. Among authors: okaniwa m. Cancer Res Commun. 2022 Jun 23;2(6):489-502. doi: 10.1158/2767-9764.CRC-21-0161. eCollection 2022 Jun. Cancer Res Commun. 2022. PMID: 36923556 Free PMC article.
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity.
Dane EL, Belessiotis-Richards A, Backlund C, Wang J, Hidaka K, Milling LE, Bhagchandani S, Melo MB, Wu S, Li N, Donahue N, Ni K, Ma L, Okaniwa M, Stevens MM, Alexander-Katz A, Irvine DJ. Dane EL, et al. Among authors: okaniwa m. Nat Mater. 2022 Jun;21(6):710-720. doi: 10.1038/s41563-022-01251-z. Epub 2022 May 23. Nat Mater. 2022. PMID: 35606429 Free PMC article.
A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity.
Ohashi A, Ohori M, Iwai K, Nambu T, Miyamoto M, Kawamoto T, Okaniwa M. Ohashi A, et al. Among authors: okaniwa m. PLoS One. 2015 Dec 9;10(12):e0144675. doi: 10.1371/journal.pone.0144675. eCollection 2015. PLoS One. 2015. PMID: 26649895 Free PMC article.
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.
Okaniwa M, Hirose M, Arita T, Yabuki M, Nakamura A, Takagi T, Kawamoto T, Uchiyama N, Sumita A, Tsutsumi S, Tottori T, Inui Y, Sang BC, Yano J, Aertgeerts K, Yoshida S, Ishikawa T. Okaniwa M, et al. J Med Chem. 2013 Aug 22;56(16):6478-94. doi: 10.1021/jm400778d. Epub 2013 Aug 1. J Med Chem. 2013. PMID: 23906342
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
Tanaka Y, Kurasawa O, Yokota A, Klein MG, Ono K, Saito B, Matsumoto S, Okaniwa M, Ambrus-Aikelin G, Morishita D, Kitazawa S, Uchiyama N, Ogawa K, Kimura H, Imamura S. Tanaka Y, et al. Among authors: okaniwa m. J Med Chem. 2020 Mar 26;63(6):3215-3226. doi: 10.1021/acs.jmedchem.9b01979. Epub 2020 Mar 16. J Med Chem. 2020. PMID: 32142284
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
Tanaka Y, Kurasawa O, Yokota A, Klein MG, Saito B, Matsumoto S, Okaniwa M, Ambrus-Aikelin G, Uchiyama N, Morishita D, Kimura H, Imamura S. Tanaka Y, et al. Among authors: okaniwa m. ACS Med Chem Lett. 2020 Jul 30;11(8):1645-1652. doi: 10.1021/acsmedchemlett.0c00331. eCollection 2020 Aug 13. ACS Med Chem Lett. 2020. PMID: 34345355 Free PMC article.
Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents.
Hirayama T, Okaniwa M, Banno H, Kakei H, Ohashi A, Iwai K, Ohori M, Mori K, Gotou M, Kawamoto T, Yokota A, Ishikawa T. Hirayama T, et al. Among authors: okaniwa m. J Med Chem. 2015 Oct 22;58(20):8036-53. doi: 10.1021/acs.jmedchem.5b00836. Epub 2015 Oct 1. J Med Chem. 2015. PMID: 26372373
42 results