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Macrophage specific restoration of the Nrf2 gene in whole-body knockout mice ameliorates steatohepatitis induced by lipopolysaccharide from Porphyromonas gingivalis through enhanced hepatic clearance.
Chihara K, Okada K, Uchida F, Miura I, Komine S, Warabi E, Takayama T, Suzuki H, Matsuzaka T, Ishibashi-Kanno N, Yamagata K, Yanagawa T, Bukawa H, Shoda J. Chihara K, et al. Among authors: okada k. PLoS One. 2023 Oct 20;18(10):e0291880. doi: 10.1371/journal.pone.0291880. eCollection 2023. PLoS One. 2023. PMID: 37862331 Free PMC article.
Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.
Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H. Okada K, et al. Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1450-63. doi: 10.1152/ajpgi.00302.2006. Epub 2006 Oct 12. Am J Physiol Gastrointest Liver Physiol. 2007. PMID: 17038627 Free article.
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.
Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Takeda K, Utsunomiya H, Oda K, Warabi E, Ishii T, Osaka K, Hyodo I, Yamamoto M. Okada K, et al. Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G735-47. doi: 10.1152/ajpgi.90321.2008. Epub 2008 Aug 7. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18687751 Free article.
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.
Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Sugimoto H, Utsunomiya H, Oda K, Warabi E, Ishii T, Yamamoto M. Okada K, et al. Biochem Biophys Res Commun. 2009 Nov 20;389(3):431-6. doi: 10.1016/j.bbrc.2009.08.156. Epub 2009 Sep 2. Biochem Biophys Res Commun. 2009. PMID: 19732748
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice.
Sugimoto H, Okada K, Shoda J, Warabi E, Ishige K, Ueda T, Taguchi K, Yanagawa T, Nakahara A, Hyodo I, Ishii T, Yamamoto M. Sugimoto H, et al. Among authors: okada k. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G283-94. doi: 10.1152/ajpgi.00296.2009. Epub 2009 Nov 19. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 19926817 Free article.
5,883 results