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Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs.
Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao R, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, Irimura T. Hayakawa Y, et al. Among authors: ohtsu a. Cancer Sci. 2016 Feb;107(2):189-202. doi: 10.1111/cas.12857. Cancer Sci. 2016. PMID: 26919617 Free PMC article. Review.
Phase I trial of chemoradiotherapy with the combination of S-1 plus cisplatin for patients with unresectable locally advanced squamous cell carcinoma of the head and neck.
Tahara M, Minami H, Kawashima M, Kawada K, Mukai H, Sakuraba M, Matsuura K, Ogino T, Hayashi R, Ohtsu A. Tahara M, et al. Among authors: ohtsu a. Cancer Sci. 2011 Feb;102(2):419-24. doi: 10.1111/j.1349-7006.2010.01799.x. Epub 2010 Dec 7. Cancer Sci. 2011. PMID: 21134076 Free article. Clinical Trial.
Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).
Shitara K, Doi T, Nagano O, Imamura CK, Ozeki T, Ishii Y, Tsuchihashi K, Takahashi S, Nakajima TE, Hironaka S, Fukutani M, Hasegawa H, Nomura S, Sato A, Einaga Y, Kuwata T, Saya H, Ohtsu A. Shitara K, et al. Among authors: ohtsu a. Gastric Cancer. 2017 Mar;20(2):341-349. doi: 10.1007/s10120-016-0610-8. Epub 2016 Apr 7. Gastric Cancer. 2017. PMID: 27055559
Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).
Shitara K, Doi T, Nagano O, Fukutani M, Hasegawa H, Nomura S, Sato A, Kuwata T, Asai K, Einaga Y, Tsuchihashi K, Suina K, Maeda Y, Saya H, Ohtsu A. Shitara K, et al. Among authors: ohtsu a. Gastric Cancer. 2017 Nov;20(6):1004-1009. doi: 10.1007/s10120-017-0720-y. Epub 2017 May 2. Gastric Cancer. 2017. PMID: 28466360 Clinical Trial.
456 results