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pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases.
Mena-Barragán T, Narita A, Matias D, Tiscornia G, Nanba E, Ohno K, Suzuki Y, Higaki K, Garcia Fernández JM, Ortiz Mellet C. Mena-Barragán T, et al. Among authors: ohno k. Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11696-700. doi: 10.1002/anie.201505147. Epub 2015 Aug 7. Angew Chem Int Ed Engl. 2015. PMID: 26386364
Chemical chaperone therapy: chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency.
Higaki K, Li L, Bahrudin U, Okuzawa S, Takamuram A, Yamamoto K, Adachi K, Paraguison RC, Takai T, Ikehata H, Tominaga L, Hisatome I, Iida M, Ogawa S, Matsuda J, Ninomiya H, Sakakibara Y, Ohno K, Suzuki Y, Nanba E. Higaki K, et al. Among authors: ohno k. Hum Mutat. 2011 Jul;32(7):843-52. doi: 10.1002/humu.21516. Hum Mutat. 2011. PMID: 21520340
A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.
Takai T, Higaki K, Aguilar-Moncayo M, Mena-Barragán T, Hirano Y, Yura K, Yu L, Ninomiya H, García-Moreno MI, Sakakibara Y, Ohno K, Nanba E, Ortiz Mellet C, García Fernández JM, Suzuki Y. Takai T, et al. Among authors: ohno k. Mol Ther. 2013 Mar;21(3):526-32. doi: 10.1038/mt.2012.263. Epub 2013 Jan 22. Mol Ther. 2013. PMID: 23337983 Free PMC article.
Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier.
Rodríguez-Lavado J, de la Mata M, Jiménez-Blanco JL, García-Moreno MI, Benito JM, Díaz-Quintana A, Sánchez-Alcázar JA, Higaki K, Nanba E, Ohno K, Suzuki Y, Ortiz Mellet C, García Fernández JM. Rodríguez-Lavado J, et al. Among authors: ohno k. Org Biomol Chem. 2014 Apr 14;12(14):2289-301. doi: 10.1039/c3ob42530d. Org Biomol Chem. 2014. PMID: 24589885
Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants.
Yu Y, Mena-Barragán T, Higaki K, Johnson JL, Drury JE, Lieberman RL, Nakasone N, Ninomiya H, Tsukimura T, Sakuraba H, Suzuki Y, Nanba E, Mellet CO, García Fernández JM, Ohno K. Yu Y, et al. Among authors: ohno k. ACS Chem Biol. 2014 Jul 18;9(7):1460-9. doi: 10.1021/cb500143h. Epub 2014 May 12. ACS Chem Biol. 2014. PMID: 24783948
Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis.
Takamura A, Higaki K, Kajimaki K, Otsuka S, Ninomiya H, Matsuda J, Ohno K, Suzuki Y, Nanba E. Takamura A, et al. Among authors: ohno k. Biochem Biophys Res Commun. 2008 Mar 14;367(3):616-22. doi: 10.1016/j.bbrc.2007.12.187. Epub 2008 Jan 9. Biochem Biophys Res Commun. 2008. PMID: 18190792
2,330 results