Ohkubo R - Search Results

1

The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging.

Wang CL, Ohkubo R, Mu WC, Chen W, Fan JL, Song Z, Maruichi A, Sudmant PH, Pisco AO, Dubal DB, Ji N, Chen D. Wang CL, et al. Among authors: ohkubo r. Cell Metab. 2023 Jun 6;35(6):996-1008.e7. doi: 10.1016/j.cmet.2023.04.012. Epub 2023 May 4. Cell Metab. 2023. PMID: 37146607

2

Aging: rewiring the circadian clock.

Ohkubo R, Chen D. Ohkubo R, et al. Nat Struct Mol Biol. 2017 Sep 7;24(9):687-688. doi: 10.1038/nsmb.3461. Nat Struct Mol Biol. 2017. PMID: 28880862 Free PMC article.

3

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.

Luo H, Mu WC, Karki R, Chiang HH, Mohrin M, Shin JJ, Ohkubo R, Ito K, Kanneganti TD, Chen D. Luo H, et al. Among authors: ohkubo r. Cell Rep. 2019 Jan 22;26(4):945-954.e4. doi: 10.1016/j.celrep.2018.12.101. Cell Rep. 2019. PMID: 30673616 Free PMC article.

4

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance.

He M, Chiang HH, Luo H, Zheng Z, Qiao Q, Wang L, Tan M, Ohkubo R, Mu WC, Zhao S, Wu H, Chen D. He M, et al. Among authors: ohkubo r. Cell Metab. 2020 Mar 3;31(3):580-591.e5. doi: 10.1016/j.cmet.2020.01.009. Epub 2020 Feb 6. Cell Metab. 2020. PMID: 32032542 Free PMC article.

5

The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation.

Mu WC, Ohkubo R, Widjaja A, Chen D. Mu WC, et al. Among authors: ohkubo r. Mech Ageing Dev. 2020 Jun;188:111254. doi: 10.1016/j.mad.2020.111254. Epub 2020 Apr 25. Mech Ageing Dev. 2020. PMID: 32343979 Free PMC article. Review.

6

The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease.

Ohkubo R, Mu WC, Wang CL, Song Z, Barthez M, Wang Y, Mitchener N, Abdullayev R, Lee YR, Ma Y, Curtin M, Srinivasan S, Zhang X, Yang F, Sudmant PH, Pisco AO, Neff N, Haynes CM, Chen D. Ohkubo R, et al. Cell Rep. 2022 Dec 13;41(11):111803. doi: 10.1016/j.celrep.2022.111803. Cell Rep. 2022. PMID: 36516757 Free PMC article.

7

Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy.

Sato T, Nagai M, Watanabe O, Misu T, Takenouchi N, Ohkubo R, Ishihara S, Tsuboi Y, Katsuno M, Nakagawa M, Matsushita T, Aso Y, Matsuura E, Tokashiki T, Mukaino A, Adachi H, Nakanishi K, Yamaguchi Y, Yamaguchi S, Yamano Y. Sato T, et al. Among authors: ohkubo r. J Neurol. 2024 Mar 2. doi: 10.1007/s00415-024-12239-x. Online ahead of print. J Neurol. 2024. PMID: 38430272

8

Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.

McEachin ZT, Gendron TF, Raj N, García-Murias M, Banerjee A, Purcell RH, Ward PJ, Todd TW, Merritt-Garza ME, Jansen-West K, Hales CM, García-Sobrino T, Quintáns B, Holler CJ, Taylor G, San Millán B, Teijeira S, Yamashita T, Ohkubo R, Boulis NM, Xu C, Wen Z, Streichenberger N; Neuro–CEB Neuropathology Network; Fogel BL, Kukar T, Abe K, Dickson DW, Arias M, Glass JD, Jiang J, Tansey MG, Sobrido MJ, Petrucelli L, Rossoll W, Bassell GJ. McEachin ZT, et al. Among authors: ohkubo r. Neuron. 2020 Jul 22;107(2):292-305.e6. doi: 10.1016/j.neuron.2020.04.011. Epub 2020 May 5. Neuron. 2020. PMID: 32375063 Free PMC article.

9

A high titer of acquired factor V inhibitor in a hemodialysis patient who developed arterial thrombosis.

Ogawa H, Souri M, Kanouchi K, Osaki T, Ohkubo R, Kawanishi T, Wakai S, Morikane K, Ichinose A. Ogawa H, et al. Among authors: ohkubo r. Int J Hematol. 2019 Feb;109(2):214-220. doi: 10.1007/s12185-018-2561-9. Epub 2018 Nov 16. Int J Hematol. 2019. PMID: 30446942

10

A novel PHOX2B gene mutation in an extremely low birth weight infant with congenital central hypoventilation syndrome and variant Hirschsprung's disease.

Miura Y, Watanabe T, Uchida T, Nawa T, Endo N, Fukuzawa T, Ohkubo R, Takeyama J, Sasaki A, Hayasaka K. Miura Y, et al. Among authors: ohkubo r. Eur J Med Genet. 2019 Sep;62(9):103541. doi: 10.1016/j.ejmg.2018.09.008. Epub 2018 Sep 15. Eur J Med Genet. 2019. PMID: 30227298

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