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Discovery of novel tricyclic compounds as squalene synthase inhibitors.
Ichikawa M, Ohtsuka M, Ohki H, Haginoya N, Itoh M, Sugita K, Usui H, Suzuki M, Terayama K, Kanda A. Ichikawa M, et al. Among authors: ohki h. Bioorg Med Chem. 2012 May 1;20(9):3072-93. doi: 10.1016/j.bmc.2012.02.054. Epub 2012 Mar 8. Bioorg Med Chem. 2012. PMID: 22464687
Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents.
Inagaki H, Miyauchi S, Miyauchi RN, Kawato HC, Ohki H, Matsuhashi N, Kawakami K, Takahashi H, Takemura M. Inagaki H, et al. Among authors: ohki h. J Med Chem. 2003 Mar 13;46(6):1005-15. doi: 10.1021/jm020328y. J Med Chem. 2003. PMID: 12620077
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.
Miyauchi R, Kawakami K, Ito M, Matsuhashi N, Ohki H, Inagaki H, Takahashi H, Takemura M. Miyauchi R, et al. Among authors: ohki h. Bioorg Med Chem. 2009 Oct 1;17(19):6879-89. doi: 10.1016/j.bmc.2009.08.026. Epub 2009 Aug 20. Bioorg Med Chem. 2009. PMID: 19736016
Discovery of DF-461, a Potent Squalene Synthase Inhibitor.
Ichikawa M, Ohtsuka M, Ohki H, Ota M, Haginoya N, Itoh M, Shibata Y, Ishigai Y, Terayama K, Kanda A, Sugita K. Ichikawa M, et al. Among authors: ohki h. ACS Med Chem Lett. 2013 Sep 4;4(10):932-6. doi: 10.1021/ml400151c. eCollection 2013 Oct 10. ACS Med Chem Lett. 2013. PMID: 24900587 Free PMC article.
103 results