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327 results

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Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.
Hezaveh K, Shinde RS, Klötgen A, Halaby MJ, Lamorte S, Ciudad MT, Quevedo R, Neufeld L, Liu ZQ, Jin R, Grünwald BT, Foerster EG, Chaharlangi D, Guo M, Makhijani P, Zhang X, Pugh TJ, Pinto DM, Co IL, McGuigan AP, Jang GH, Khokha R, Ohashi PS, O'Kane GM, Gallinger S, Navarre WW, Maughan H, Philpott DJ, Brooks DG, McGaha TL. Hezaveh K, et al. Among authors: ohashi ps. Immunity. 2022 Feb 8;55(2):324-340.e8. doi: 10.1016/j.immuni.2022.01.006. Immunity. 2022. PMID: 35139353 Free PMC article.
A distinct innate lymphoid cell population regulates tumor-associated T cells.
Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier LL, Ohashi PS. Crome SQ, et al. Among authors: ohashi ps. Nat Med. 2017 Mar;23(3):368-375. doi: 10.1038/nm.4278. Epub 2017 Feb 6. Nat Med. 2017. PMID: 28165478 Free PMC article.
Notch Shapes the Innate Immunophenotype in Breast Cancer.
Shen Q, Cohen B, Zheng W, Rahbar R, Martin B, Murakami K, Lamorte S, Thompson P, Berman H, Zúñiga-Pflücker JC, Ohashi PS, Reedijk M. Shen Q, et al. Among authors: ohashi ps. Cancer Discov. 2017 Nov;7(11):1320-1335. doi: 10.1158/2159-8290.CD-17-0037. Epub 2017 Aug 8. Cancer Discov. 2017. PMID: 28790030
Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma.
Toker A, Nguyen LT, Stone SC, Yang SYC, Katz SR, Shaw PA, Clarke BA, Ghazarian D, Al-Habeeb A, Easson A, Leong WL, McCready DR, Reedijk M, Guidos CJ, Pugh TJ, Bernardini MQ, Ohashi PS. Toker A, et al. Among authors: ohashi ps. Clin Cancer Res. 2018 Nov 15;24(22):5685-5696. doi: 10.1158/1078-0432.CCR-18-0554. Epub 2018 Jul 31. Clin Cancer Res. 2018. PMID: 30065096
CapTCR-seq: hybrid capture for T-cell receptor repertoire profiling.
Mulder DT, Mahé ER, Dowar M, Hanna Y, Li T, Nguyen LT, Butler MO, Hirano N, Delabie J, Ohashi PS, Pugh TJ. Mulder DT, et al. Among authors: ohashi ps. Blood Adv. 2018 Dec 11;2(23):3506-3514. doi: 10.1182/bloodadvances.2017014639. Blood Adv. 2018. PMID: 30530777 Free PMC article.
An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE).
Clouthier DL, Lien SC, Yang SYC, Nguyen LT, Manem VSK, Gray D, Ryczko M, Razak ARA, Lewin J, Lheureux S, Colombo I, Bedard PL, Cescon D, Spreafico A, Butler MO, Hansen AR, Jang RW, Ghai S, Weinreb I, Sotov V, Gadalla R, Noamani B, Guo M, Elston S, Giesler A, Hakgor S, Jiang H, McGaha T, Brooks DG, Haibe-Kains B, Pugh TJ, Ohashi PS, Siu LL. Clouthier DL, et al. Among authors: ohashi ps. J Immunother Cancer. 2019 Mar 13;7(1):72. doi: 10.1186/s40425-019-0541-0. J Immunother Cancer. 2019. PMID: 30867072 Free PMC article. Clinical Trial.
Turning the Tide Against Regulatory T Cells.
Han S, Toker A, Liu ZQ, Ohashi PS. Han S, et al. Among authors: ohashi ps. Front Oncol. 2019 Apr 16;9:279. doi: 10.3389/fonc.2019.00279. eCollection 2019. Front Oncol. 2019. PMID: 31058083 Free PMC article. Review.
GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment.
Halaby MJ, Hezaveh K, Lamorte S, Ciudad MT, Kloetgen A, MacLeod BL, Guo M, Chakravarthy A, Medina TDS, Ugel S, Tsirigos A, Bronte V, Munn DH, Pugh TJ, De Carvalho DD, Butler MO, Ohashi PS, Brooks DG, McGaha TL. Halaby MJ, et al. Among authors: ohashi ps. Sci Immunol. 2019 Dec 13;4(42):eaax8189. doi: 10.1126/sciimmunol.aax8189. Sci Immunol. 2019. PMID: 31836669 Free PMC article.
327 results