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The ubiquinone synthesis pathway is a promising drug target for Chagas disease.
Nara T, Nakagawa Y, Tsuganezawa K, Yuki H, Sekimata K, Koyama H, Ogawa N, Honma T, Shirouzu M, Fukami T, Matsuo Y, Inaoka DK, Kita K, Tanaka A. Nara T, et al. Among authors: ogawa n. PLoS One. 2021 Feb 4;16(2):e0243855. doi: 10.1371/journal.pone.0243855. eCollection 2021. PLoS One. 2021. PMID: 33539347 Free PMC article.
Identification of small molecule inhibitors of human COQ7.
Tsuganezawa K, Sekimata K, Nakagawa Y, Utata R, Nakamura K, Ogawa N, Koyama H, Shirouzu M, Fukami T, Kita K, Tanaka A. Tsuganezawa K, et al. Among authors: ogawa n. Bioorg Med Chem. 2020 Jan 1;28(1):115182. doi: 10.1016/j.bmc.2019.115182. Epub 2019 Nov 9. Bioorg Med Chem. 2020. PMID: 31753803
A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide.
Tsuganezawa K, Watanabe H, Parker L, Yuki H, Taruya S, Nakagawa Y, Kamei D, Mori M, Ogawa N, Tomabechi Y, Handa N, Honma T, Yokoyama S, Kojima H, Okabe T, Nagano T, Tanaka A. Tsuganezawa K, et al. Among authors: ogawa n. J Mol Biol. 2012 Mar 30;417(3):240-52. doi: 10.1016/j.jmb.2012.01.036. Epub 2012 Jan 30. J Mol Biol. 2012. PMID: 22306408
Insights from Pim1 structure for anti-cancer drug design.
Ogawa N, Yuki H, Tanaka A. Ogawa N, et al. Expert Opin Drug Discov. 2012 Dec;7(12):1177-92. doi: 10.1517/17460441.2012.727394. Epub 2012 Sep 25. Expert Opin Drug Discov. 2012. PMID: 23004574 Review.
Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor.
Parker LJ, Watanabe H, Tsuganezawa K, Tomabechi Y, Handa N, Shirouzu M, Yuki H, Honma T, Ogawa N, Nagano T, Yokoyama S, Tanaka A. Parker LJ, et al. Among authors: ogawa n. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):860-6. doi: 10.1107/S1744309112027108. Epub 2012 Jul 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 22869110 Free PMC article.
A fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53.
Tsuganezawa K, Nakagawa Y, Kato M, Taruya S, Takahashi F, Endoh M, Utata R, Mori M, Ogawa N, Honma T, Yokoyama S, Hashizume Y, Aoki M, Kasai T, Kigawa T, Kojima H, Okabe T, Nagano T, Tanaka A. Tsuganezawa K, et al. Among authors: ogawa n. J Biomol Screen. 2013 Feb;18(2):191-8. doi: 10.1177/1087057112460729. Epub 2012 Sep 18. J Biomol Screen. 2013. PMID: 22989451
Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies.
Takaya D, Inaka K, Omura A, Takenuki K, Kawanishi M, Yabuki Y, Nakagawa Y, Tsuganezawa K, Ogawa N, Watanabe C, Honma T, Aritake K, Urade Y, Shirouzu M, Tanaka A. Takaya D, et al. Among authors: ogawa n. Bioorg Med Chem. 2018 Sep 1;26(16):4726-4734. doi: 10.1016/j.bmc.2018.08.014. Epub 2018 Aug 11. Bioorg Med Chem. 2018. PMID: 30121213
1,642 results