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Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters.
Keshavarz M, Faraj Tabrizi S, Ruppert AL, Pfeil U, Schreiber Y, Klein J, Brandenburger I, Lochnit G, Bhushan S, Perniss A, Deckmann K, Hartmann P, Meiners M, Mermer P, Rafiq A, Winterberg S, Papadakis T, Thomas D, Angioni C, Oberwinkler J, Chubanov V, Gudermann T, Gärtner U, Offermanns S, Schütz B, Kummer W. Keshavarz M, et al. Among authors: offermanns s. Sci Immunol. 2022 Mar 4;7(69):eabf6734. doi: 10.1126/sciimmunol.abf6734. Epub 2022 Mar 4. Sci Immunol. 2022. PMID: 35245090
The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.
Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, Scholich K. Zinn S, et al. Among authors: offermanns s. J Biol Chem. 2017 Apr 14;292(15):6123-6134. doi: 10.1074/jbc.M116.769125. Epub 2017 Feb 27. J Biol Chem. 2017. PMID: 28242764 Free PMC article.
Helix 8 is the essential structural motif of mechanosensitive GPCRs.
Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos Y Schnitzler M. Erdogmus S, et al. Among authors: offermanns s. Nat Commun. 2019 Dec 19;10(1):5784. doi: 10.1038/s41467-019-13722-0. Nat Commun. 2019. PMID: 31857598 Free PMC article.
Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.
Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert AL, Timm T, Pfeil U, Soultanova A, Kusumakshi S, Delventhal L, Aydin Ö, Pyrski M, Deckmann K, Hain T, Schmidt N, Ewers C, Günther A, Lochnit G, Chubanov V, Gudermann T, Oberwinkler J, Klein J, Mikoshiba K, Leinders-Zufall T, Offermanns S, Schütz B, Boehm U, Zufall F, Bufe B, Kummer W. Perniss A, et al. Among authors: offermanns s. Immunity. 2020 Apr 14;52(4):683-699.e11. doi: 10.1016/j.immuni.2020.03.005. Immunity. 2020. PMID: 32294408 Free article.
A succinate/SUCNR1-brush cell defense program in the tracheal epithelium.
Perniss A, Boonen B, Tonack S, Thiel M, Poharkar K, Alnouri MW, Keshavarz M, Papadakis T, Wiegand S, Pfeil U, Richter K, Althaus M, Oberwinkler J, Schütz B, Boehm U, Offermanns S, Leinders-Zufall T, Zufall F, Kummer W. Perniss A, et al. Among authors: offermanns s. Sci Adv. 2023 Aug 2;9(31):eadg8842. doi: 10.1126/sciadv.adg8842. Epub 2023 Aug 2. Sci Adv. 2023. PMID: 37531421 Free PMC article.
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.
Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T, Ghofrani HA, Dietrich A. Weissmann N, et al. Among authors: offermanns s. Nat Commun. 2012 Jan 31;3:649. doi: 10.1038/ncomms1660. Nat Commun. 2012. PMID: 22337127 Free PMC article.
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling.
Khatib-Massalha E, Bhattacharya S, Massalha H, Biram A, Golan K, Kollet O, Kumari A, Avemaria F, Petrovich-Kopitman E, Gur-Cohen S, Itkin T, Brandenburger I, Spiegel A, Shulman Z, Gerhart-Hines Z, Itzkovitz S, Gunzer M, Offermanns S, Alon R, Ariel A, Lapidot T. Khatib-Massalha E, et al. Among authors: offermanns s. Nat Commun. 2020 Jul 15;11(1):3547. doi: 10.1038/s41467-020-17402-2. Nat Commun. 2020. PMID: 32669546 Free PMC article.
371 results