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The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. Wenzel J, et al. Among authors: ofengeim d. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. Nat Neurosci. 2021. PMID: 34675436 Free PMC article.
Sound transmission in the lung as a function of lung volume.
Bergstresser T, Ofengeim D, Vyshedskiy A, Shane J, Murphy R. Bergstresser T, et al. Among authors: ofengeim d. J Appl Physiol (1985). 2002 Aug;93(2):667-74. doi: 10.1152/japplphysiol.00050.2002. J Appl Physiol (1985). 2002. PMID: 12133878 Free article.
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration.
Ryan SK, Zelic M, Han Y, Teeple E, Chen L, Sadeghi M, Shankara S, Guo L, Li C, Pontarelli F, Jensen EH, Comer AL, Kumar D, Zhang M, Gans J, Zhang B, Proto JD, Saleh J, Dodge JC, Savova V, Rajpal D, Ofengeim D, Hammond TR. Ryan SK, et al. Among authors: ofengeim d. Nat Neurosci. 2023 Jan;26(1):12-26. doi: 10.1038/s41593-022-01221-3. Epub 2022 Dec 19. Nat Neurosci. 2023. PMID: 36536241 Free PMC article.
CSF1R signaling is a regulator of pathogenesis in progressive MS.
Hagan N, Kane JL, Grover D, Woodworth L, Madore C, Saleh J, Sancho J, Liu J, Li Y, Proto J, Zelic M, Mahan A, Kothe M, Scholte AA, Fitzgerald M, Gisevius B, Haghikia A, Butovsky O, Ofengeim D. Hagan N, et al. Among authors: ofengeim d. Cell Death Dis. 2020 Oct 23;11(10):904. doi: 10.1038/s41419-020-03084-7. Cell Death Dis. 2020. PMID: 33097690 Free PMC article.
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M. Jafari M, et al. Among authors: ofengeim d. Nat Neurosci. 2021 Mar;24(3):355-367. doi: 10.1038/s41593-020-00780-7. Epub 2021 Jan 25. Nat Neurosci. 2021. PMID: 33495636
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis.
Zelic M, Pontarelli F, Woodworth L, Zhu C, Mahan A, Ren Y, LaMorte M, Gruber R, Keane A, Loring P, Guo L, Xia TH, Zhang B, Orning P, Lien E, Degterev A, Hammond T, Ofengeim D. Zelic M, et al. Among authors: ofengeim d. Cell Rep. 2021 May 11;35(6):109112. doi: 10.1016/j.celrep.2021.109112. Cell Rep. 2021. PMID: 33979622 Free PMC article.
N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.
Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA. Ofengeim D, et al. Nat Neurosci. 2012 Feb 26;15(4):574-80. doi: 10.1038/nn.3054. Nat Neurosci. 2012. PMID: 22366758 Free PMC article.
35 results