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Structure-guided microbial targeting of antistaphylococcal prodrugs.
Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Hoops GC, Johnson RJ, Planet PJ, Muller FL, Jez JM, Odom John AR. Miller JJ, et al. Among authors: odom john ar. Elife. 2021 Jul 19;10:e66657. doi: 10.7554/eLife.66657. Elife. 2021. PMID: 34279224 Free PMC article.
MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.
Wang X, Edwards RL, Ball H, Johnson C, Haymond A, Girma M, Manikkam M, Brothers RC, McKay KT, Arnett SD, Osbourn DM, Alvarez S, Boshoff HI, Meyers MJ, Couch RD, Odom John AR, Dowd CS. Wang X, et al. Among authors: odom john ar. J Med Chem. 2018 Oct 11;61(19):8847-8858. doi: 10.1021/acs.jmedchem.8b01026. Epub 2018 Sep 24. J Med Chem. 2018. PMID: 30192536 Free PMC article.
Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.
Heitmeier MR, Hresko RC, Edwards RL, Prinsen MJ, Ilagan MXG, Odom John AR, Hruz PW. Heitmeier MR, et al. Among authors: odom john ar. PLoS One. 2019 May 9;14(5):e0216457. doi: 10.1371/journal.pone.0216457. eCollection 2019. PLoS One. 2019. PMID: 31071153 Free PMC article.
The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation.
Henrici RC, Edwards RL, Zoltner M, van Schalkwyk DA, Hart MN, Mohring F, Moon RW, Nofal SD, Patel A, Flueck C, Baker DA, Odom John AR, Field MC, Sutherland CJ. Henrici RC, et al. Among authors: odom john ar. mBio. 2020 Feb 25;11(1):e02918-19. doi: 10.1128/mBio.02918-19. mBio. 2020. PMID: 32098816 Free PMC article.
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
Gnädig NF, Stokes BH, Edwards RL, Kalantarov GF, Heimsch KC, Kuderjavy M, Crane A, Lee MCS, Straimer J, Becker K, Trakht IN, Odom John AR, Mok S, Fidock DA. Gnädig NF, et al. Among authors: odom john ar. PLoS Pathog. 2020 Apr 20;16(4):e1008482. doi: 10.1371/journal.ppat.1008482. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32310999 Free PMC article.
Potent, specific MEPicides for treatment of zoonotic staphylococci.
Edwards RL, Heueck I, Lee SG, Shah IT, Miller JJ, Jezewski AJ, Mikati MO, Wang X, Brothers RC, Heidel KM, Osbourn DM, Burnham CD, Alvarez S, Fritz SA, Dowd CS, Jez JM, Odom John AR. Edwards RL, et al. Among authors: odom john ar. PLoS Pathog. 2020 Jun 4;16(6):e1007806. doi: 10.1371/journal.ppat.1007806. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32497104 Free PMC article.
Antimicrobial Prodrug Activation by the Staphylococcal Glyoxalase GloB.
Mikati MO, Miller JJ, Osbourn DM, Barekatain Y, Ghebremichael N, Shah IT, Burnham CD, Heidel KM, Yan VC, Muller FL, Dowd CS, Edwards RL, Odom John AR. Mikati MO, et al. Among authors: odom john ar. ACS Infect Dis. 2020 Nov 13;6(11):3064-3075. doi: 10.1021/acsinfecdis.0c00582. Epub 2020 Oct 29. ACS Infect Dis. 2020. PMID: 33118347 Free PMC article.
Targeting Host Glycolysis as a Strategy for Antimalarial Development.
Jezewski AJ, Lin YH, Reisz JA, Culp-Hill R, Barekatain Y, Yan VC, D'Alessandro A, Muller FL, Odom John AR. Jezewski AJ, et al. Among authors: odom john ar. Front Cell Infect Microbiol. 2021 Sep 16;11:730413. doi: 10.3389/fcimb.2021.730413. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34604112 Free PMC article.
48 results