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Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors.
Amberg W, Lange UEW, Ochse M, Pohlki F, Behl B, Relo AL, Hornberger W, Hoft C, Mezler M, Sydor J, Wang Y, Zhao H, Brewer JT, Dietrich J, Li H, Akritopoulou-Zanze I, Lao Y, Hannick SM, Ku YY, Vasudevan A. Amberg W, et al. Among authors: ochse m. J Med Chem. 2018 Sep 13;61(17):7503-7524. doi: 10.1021/acs.jmedchem.8b00300. Epub 2018 Aug 27. J Med Chem. 2018. PMID: 30080045
Inhibitors of GlyT1 affect glycine transport via discrete binding sites.
Mezler M, Hornberger W, Mueller R, Schmidt M, Amberg W, Braje W, Ochse M, Schoemaker H, Behl B. Mezler M, et al. Among authors: ochse m. Mol Pharmacol. 2008 Dec;74(6):1705-15. doi: 10.1124/mol.108.049312. Epub 2008 Sep 24. Mol Pharmacol. 2008. PMID: 18815213
A brain-like neural network for periodicity analysis.
Voutsas K, Langner G, Adamy J, Ochse M. Voutsas K, et al. Among authors: ochse m. IEEE Trans Syst Man Cybern B Cybern. 2005 Feb;35(1):12-22. doi: 10.1109/tsmcb.2004.837751. IEEE Trans Syst Man Cybern B Cybern. 2005. PMID: 15719929