O'Toole T - Search Results

1

Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits.

Rodriguez E, Boelaars K, Brown K, Madunić K, van Ee T, Dijk F, Verheij J, Li RJE, Schetters STT, Meijer LL, Le Large TYS, Driehuis E, Clevers H, Bruijns SCM, O'Toole T, van Vliet SJ, Bijlsma MF, Wuhrer M, Kazemier G, Giovannetti E, Garcia-Vallejo JJ, van Kooyk Y. Rodriguez E, et al. Commun Biol. 2022 Jan 11;5(1):41. doi: 10.1038/s42003-021-02934-0. Commun Biol. 2022. PMID: 35017635 Free PMC article.

2

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8⁺ T cell apoptosis.

Cornelissen LAM, Blanas A, van der Horst JC, Kruijssen L, Zaal A, O'Toole T, Wiercx L, van Kooyk Y, van Vliet SJ. Cornelissen LAM, et al. Int J Cancer. 2019 May 1;144(9):2290-2302. doi: 10.1002/ijc.32084. Epub 2019 Jan 3. Int J Cancer. 2019. PMID: 30578646 Free PMC article.

3

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer.

Cornelissen LAM, Blanas A, Zaal A, van der Horst JC, Kruijssen LJW, O'Toole T, van Kooyk Y, van Vliet SJ. Cornelissen LAM, et al. Front Oncol. 2020 Aug 18;10:1622. doi: 10.3389/fonc.2020.01622. eCollection 2020. Front Oncol. 2020. PMID: 33014816 Free PMC article.

4

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.

Lopes Pinheiro MA, Kamermans A, Garcia-Vallejo JJ, van Het Hof B, Wierts L, O'Toole T, Boeve D, Verstege M, van der Pol SM, van Kooyk Y, de Vries HE, Unger WW. Lopes Pinheiro MA, et al. Elife. 2016 Jun 23;5:e13149. doi: 10.7554/eLife.13149. Elife. 2016. PMID: 27336724 Free PMC article.

5

Selective tumor antigen vaccine delivery to human CD169⁺ antigen-presenting cells using ganglioside-liposomes.

Affandi AJ, Grabowska J, Olesek K, Lopez Venegas M, Barbaria A, Rodríguez E, Mulder PPG, Pijffers HJ, Ambrosini M, Kalay H, O'Toole T, Zwart ES, Kazemier G, Nazmi K, Bikker FJ, Stöckl J, van den Eertwegh AJM, de Gruijl TD, Storm G, van Kooyk Y, den Haan JMM. Affandi AJ, et al. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27528-27539. doi: 10.1073/pnas.2006186117. Epub 2020 Oct 16. Proc Natl Acad Sci U S A. 2020. PMID: 33067394 Free PMC article.

6

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.

Verbrugge SE, Al M, Assaraf YG, Kammerer S, Chandrupatla DM, Honeywell R, Musters RP, Giovannetti E, O'Toole T, Scheffer GL, Krige D, de Gruijl TD, Niessen HW, Lems WF, Kramer PA, Scheper RJ, Cloos J, Ossenkoppele GJ, Peters GJ, Jansen G. Verbrugge SE, et al. Oncotarget. 2016 Feb 2;7(5):5240-57. doi: 10.18632/oncotarget.6169. Oncotarget. 2016. PMID: 26496029 Free PMC article.

7

Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase.

van den Brink GR, O'Toole T, Hardwick JC, van den Boogaardt DE, Versteeg HH, van Deventer SJ, Peppelenbosch MP. van den Brink GR, et al. Mol Cell Biol Res Commun. 2000 Sep;4(3):144-50. doi: 10.1006/mcbr.2001.0270. Mol Cell Biol Res Commun. 2000. PMID: 11281728

8

A yeast FRET biosensor enlightens cAMP signaling.

Botman D, O'Toole TG, Goedhart J, Bruggeman FJ, van Heerden JH, Teusink B. Botman D, et al. Mol Biol Cell. 2021 Jun 15;32(13):1229-1240. doi: 10.1091/mbc.E20-05-0319. Epub 2021 Apr 21. Mol Biol Cell. 2021. PMID: 33881352 Free PMC article.

9

Effective collaboration between marginal metallophilic macrophages and CD8+ dendritic cells in the generation of cytotoxic T cells.

Backer R, Schwandt T, Greuter M, Oosting M, Jüngerkes F, Tüting T, Boon L, O'Toole T, Kraal G, Limmer A, den Haan JM. Backer R, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):216-21. doi: 10.1073/pnas.0909541107. Epub 2009 Dec 14. Proc Natl Acad Sci U S A. 2010. PMID: 20018690 Free PMC article.

10

A Human Cell Line Model for Interferon-α Driven Dendritic Cell Differentiation.

Ruben JM, Visser LL, Heinhuis KM, O'Toole T, Bontkes HJ, Westers TM, Ossenkoppele GJ, de Gruijl TD, van de Loosdrecht AA. Ruben JM, et al. PLoS One. 2015 Aug 7;10(8):e0135219. doi: 10.1371/journal.pone.0135219. eCollection 2015. PLoS One. 2015. PMID: 26252775 Free PMC article.

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