O'Rourke M - Search Results

1

Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development.

Page N, Wappett M, O'Dowd CR, O'Rourke M, Gavory G, Zhang L, Rountree JSS, Jordan L, Barker O, Gibson H, Boyd C, Feutren-Burton S, McLean E, Trevitt G, Harrison T. Page N, et al. Sci Rep. 2022 Sep 20;12(1):15715. doi: 10.1038/s41598-022-20208-5. Sci Rep. 2022. PMID: 36127435 Free PMC article.

2

FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism.

Valentine A, O'Rourke M, Yakkundi A, Worthington J, Hookham M, Bicknell R, McCarthy HO, McClelland K, McCallum L, Dyer H, McKeen H, Waugh DJ, Roberts J, McGregor J, Cotton G, James I, Harrison T, Hirst DG, Robson T. Valentine A, et al. Clin Cancer Res. 2011 Mar 1;17(5):1044-56. doi: 10.1158/1078-0432.CCR-10-2241. Epub 2011 Mar 1. Clin Cancer Res. 2011. PMID: 21364036 Free PMC article.

3

FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy.

McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T. McKeen HD, et al. Cancer Res. 2010 Feb 1;70(3):1090-100. doi: 10.1158/0008-5472.CAN-09-2515. Epub 2010 Jan 26. Cancer Res. 2010. PMID: 20103631 Free article.

4

A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling.

McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T. McKeen HD, et al. Endocrinology. 2008 Nov;149(11):5724-34. doi: 10.1210/en.2008-0168. Epub 2008 Jul 31. Endocrinology. 2008. PMID: 18669603

5

Evaluation of the antiangiogenic potential of AQ4N.

O'Rourke M, Ward C, Worthington J, McKenna J, Valentine A, Robson T, Hirst DG, McKeown SR. O'Rourke M, et al. Clin Cancer Res. 2008 Mar 1;14(5):1502-9. doi: 10.1158/1078-0432.CCR-07-1262. Clin Cancer Res. 2008. PMID: 18316575 Free article.

6

Pericytes influence endothelial cell growth characteristics: role of plasminogen activator inhibitor type 1 (PAI-1).

McIlroy M, O'Rourke M, McKeown SR, Hirst DG, Robson T. McIlroy M, et al. Cardiovasc Res. 2006 Jan;69(1):207-17. doi: 10.1016/j.cardiores.2005.08.003. Epub 2005 Sep 13. Cardiovasc Res. 2006. PMID: 16165110

7

Vasoactivity of rucaparib, a PARP-1 inhibitor, is a complex process that involves myosin light chain kinase, P2 receptors, and PARP itself.

McCrudden CM, O'Rourke MG, Cherry KE, Yuen HF, O'Rourke D, Babur M, Telfer BA, Thomas HD, Keane P, Nambirajan T, Hagan C, O'Sullivan JM, Shaw C, Williams KJ, Curtin NJ, Hirst DG, Robson T. McCrudden CM, et al. PLoS One. 2015 Feb 17;10(2):e0118187. doi: 10.1371/journal.pone.0118187. eCollection 2015. PLoS One. 2015. PMID: 25689628 Free PMC article.

8

The complex array of bradykinin-related peptides (BRPs) in the peptidome of pickerel frog (Rana palustris) skin secretion is the product of transcriptional economy.

McCrudden CM, Zhou M, Chen T, O'Rourke M, Walker B, Hirst D, Shaw C. McCrudden CM, et al. Peptides. 2007 Jun;28(6):1275-81. doi: 10.1016/j.peptides.2007.03.019. Epub 2007 Mar 31. Peptides. 2007. PMID: 17459523

9

The smooth muscle pharmacology of maximakinin, a receptor-selective, bradykinin-related nonadecapeptide from the venom of the Chinese toad, Bombina maxima.

O'Rourke M, Chen T, Hirst DG, Rao P, Shaw C. O'Rourke M, et al. Regul Pept. 2004 Sep 15;121(1-3):65-72. doi: 10.1016/j.regpep.2004.04.007. Regul Pept. 2004. PMID: 15256275

10

Kinestatin: a novel bradykinin B2 receptor antagonist peptide from the skin secretion of the Chinese toad, Bombina maxima.

Chen T, O'Rourke M, Orr DF, Coulter DJ, Hirst DG, Rao P, Shaw C. Chen T, et al. Regul Pept. 2003 Nov 15;116(1-3):147-54. doi: 10.1016/j.regpep.2003.08.003. Regul Pept. 2003. PMID: 14599726

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