O'Neill PM - Search Results

1

Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies.

Woodley CM, Amado PSM, Cristiano MLS, O'Neill PM. Woodley CM, et al. Med Res Rev. 2021 Nov;41(6):3062-3095. doi: 10.1002/med.21849. Epub 2021 Aug 6. Med Res Rev. 2021. PMID: 34355414 Review.

2

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin.

O'Neill PM, Bishop LP, Storr RC, Hawley SR, Maggs JL, Ward SA, Park BK. O'Neill PM, et al. J Med Chem. 1996 Oct 25;39(22):4511-4. doi: 10.1021/jm9604944. J Med Chem. 1996. PMID: 8893847

3

Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.

O'Neill PM, Willock DJ, Hawley SR, Bray PG, Storr RC, Ward SA, Park BK. O'Neill PM, et al. J Med Chem. 1997 Feb 14;40(4):437-48. doi: 10.1021/jm960370r. J Med Chem. 1997. PMID: 9046333

4

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.

Hindley S, Ward SA, Storr RC, Searle NL, Bray PG, Park BK, Davies J, O'Neill PM. Hindley S, et al. J Med Chem. 2002 Feb 28;45(5):1052-63. doi: 10.1021/jm0109816. J Med Chem. 2002. PMID: 11855985

5

The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents.

O'Neill PM. O'Neill PM. Expert Opin Investig Drugs. 2005 Sep;14(9):1117-28. doi: 10.1517/13543784.14.9.1117. Expert Opin Investig Drugs. 2005. PMID: 16144496 Review.

6

An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity.

Ellis GL, Amewu R, Hall C, Rimmer K, Ward SA, O'Neill PM. Ellis GL, et al. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1720-4. doi: 10.1016/j.bmcl.2008.01.053. Epub 2008 Jan 18. Bioorg Med Chem Lett. 2008. PMID: 18243702

7

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM. Ellis GL, et al. J Med Chem. 2008 Apr 10;51(7):2170-7. doi: 10.1021/jm701435h. Epub 2008 Mar 15. J Med Chem. 2008. PMID: 18341274

8

Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.

Verissimo E, Berry N, Gibbons P, Cristiano ML, Rosenthal PJ, Gut J, Ward SA, O'Neill PM. Verissimo E, et al. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4210-4. doi: 10.1016/j.bmcl.2008.05.068. Epub 2008 May 20. Bioorg Med Chem Lett. 2008. PMID: 18554905

9

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.

Chadwick J, Mercer AE, Park BK, Cosstick R, O'Neill PM. Chadwick J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):1325-38. doi: 10.1016/j.bmc.2008.12.017. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19136263

10

Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.

O'Neill PM, Park BK, Shone AE, Maggs JL, Roberts P, Stocks PA, Biagini GA, Bray PG, Gibbons P, Berry N, Winstanley PA, Mukhtar A, Bonar-Law R, Hindley S, Bambal RB, Davis CB, Bates M, Hart TK, Gresham SL, Lawrence RM, Brigandi RA, Gomez-delas-Heras FM, Gargallo DV, Ward SA. O'Neill PM, et al. J Med Chem. 2009 Mar 12;52(5):1408-15. doi: 10.1021/jm8012618. J Med Chem. 2009. PMID: 19222165

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