O'Neill EA - Search Results

1

p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.

Natarajan SR, Wisnoski DD, Thompson JE, O'Neill EA, O'Keefe SJ. Natarajan SR, et al. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4400-4. doi: 10.1016/j.bmcl.2006.05.045. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16750629

2

Pyridazine based inhibitors of p38 MAPK.

McIntyre CJ, Ponticello GS, Liverton NJ, O'Keefe SJ, O'Neill EA, Pang M, Schwartz CD, Claremon DA. McIntyre CJ, et al. Bioorg Med Chem Lett. 2002 Feb 25;12(4):689-92. doi: 10.1016/s0960-894x(01)00834-4. Bioorg Med Chem Lett. 2002. PMID: 11844702

3

p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.

Natarajan SR, Wisnoski DD, Singh SB, Stelmach JE, O'Neill EA, Schwartz CD, Thompson CM, Fitzgerald CE, O'Keefe SJ, Kumar S, Hop CE, Zaller DM, Schmatz DM, Doherty JB. Natarajan SR, et al. Bioorg Med Chem Lett. 2003 Jan 20;13(2):273-6. doi: 10.1016/s0960-894x(02)00876-4. Bioorg Med Chem Lett. 2003. PMID: 12482438

4

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.

Stelmach JE, Liu L, Patel SB, Pivnichny JV, Scapin G, Singh S, Hop CE, Wang Z, Strauss JR, Cameron PM, Nichols EA, O'Keefe SJ, O'Neill EA, Schmatz DM, Schwartz CD, Thompson CM, Zaller DM, Doherty JB. Stelmach JE, et al. Bioorg Med Chem Lett. 2003 Jan 20;13(2):277-80. doi: 10.1016/s0960-894x(02)00752-7. Bioorg Med Chem Lett. 2003. PMID: 12482439

5

Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.

Colletti SL, Frie JL, Dixon EC, Singh SB, Choi BK, Scapin G, Fitzgerald CE, Kumar S, Nichols EA, O'Keefe SJ, O'Neill EA, Porter G, Samuel K, Schmatz DM, Schwartz CD, Shoop WL, Thompson CM, Thompson JE, Wang R, Woods A, Zaller DM, Doherty JB. Colletti SL, et al. J Med Chem. 2003 Jan 30;46(3):349-52. doi: 10.1021/jm025585h. J Med Chem. 2003. PMID: 12540232

6

p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones.

Hunt JA, Kallashi F, Ruzek RD, Sinclair PJ, Ita I, McCormick SX, Pivnichny JV, Hop CE, Kumar S, Wang Z, O'Keefe SJ, O'Neill EA, Porter G, Thompson JE, Woods A, Zaller DM, Doherty JB. Hunt JA, et al. Bioorg Med Chem Lett. 2003 Feb 10;13(3):467-70. doi: 10.1016/s0960-894x(02)00990-3. Bioorg Med Chem Lett. 2003. PMID: 12565952

7

p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.

Bao J, Hunt JA, Miao S, Rupprecht KM, Stelmach JE, Liu L, Ruzek RD, Sinclair PJ, Pivnichny JV, Hop CE, Kumar S, Zaller DM, Shoop WL, O'neill EA, O'keefe SJ, Thompson CM, Cubbon RM, Wang R, Zhang WX, Thompson JE, Doherty JB. Bao J, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):64-8. doi: 10.1016/j.bmcl.2005.09.065. Epub 2005 Oct 18. Bioorg Med Chem Lett. 2006. PMID: 16242322

8

p38 MAP kinase inhibitors. Part 5: discovery of an orally bio-available and highly efficacious compound based on the 7-amino-naphthyridone scaffold.

Natarajan SR, Liu L, Levorse M, Thompson JE, O'Neill EA, O'Keefe SJ, Vora KA, Cvetovich R, Chung JY, Carballo-Jane E, Visco DM. Natarajan SR, et al. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5468-71. doi: 10.1016/j.bmcl.2006.06.084. Epub 2006 Sep 1. Bioorg Med Chem Lett. 2006. PMID: 16945534

9

Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors.

Chen MH, Fitzgerald P, Singh SB, O'Neill EA, Schwartz CD, Thompson CM, O'Keefe SJ, Zaller DM, Doherty JB. Chen MH, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2222-6. doi: 10.1016/j.bmcl.2006.10.097. Epub 2006 Nov 6. Bioorg Med Chem Lett. 2008. PMID: 18316187

10

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

Lin S, Lombardo M, Malkani S, Hale JJ, Mills SG, Chapman K, Thompson JE, Zhang WX, Wang R, Cubbon RM, O'Neill EA, Luell S, Carballo-Jane E, Yang L. Lin S, et al. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3238-42. doi: 10.1016/j.bmcl.2009.04.088. Epub 2009 Apr 24. Bioorg Med Chem Lett. 2009. PMID: 19423344

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