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RAS in pancreatic cancer.
Lanfredini S, Thapa A, O'Neill E. Lanfredini S, et al. Biochem Soc Trans. 2019 Aug 30;47(4):961-972. doi: 10.1042/BST20170521. Epub 2019 Jul 24. Biochem Soc Trans. 2019. PMID: 31341034 Review.
TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes.
Eyres M, Lanfredini S, Xu H, Burns A, Blake A, Willenbrock F, Goldin R, Hughes D, Hughes S, Thapa A, Vavoulis D, Hubert A, D'Costa Z, Sabbagh A, Abraham AG, Blancher C, Jones S, Verrill C, Silva M, Soonawalla Z, Maughan T, Schuh A, Mukherjee S, O'Neill E. Eyres M, et al. Gastroenterology. 2021 Aug;161(2):653-668.e16. doi: 10.1053/j.gastro.2021.04.044. Epub 2021 Apr 27. Gastroenterology. 2021. PMID: 33915173
PI3K/Akt-mediated regulation of p53 in cancer.
Abraham AG, O'Neill E. Abraham AG, et al. Biochem Soc Trans. 2014 Aug;42(4):798-803. doi: 10.1042/BST20140070. Biochem Soc Trans. 2014. PMID: 25109960 Review.
RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
Papaspyropoulos A, Bradley L, Thapa A, Leung CY, Toskas K, Koennig D, Pefani DE, Raso C, Grou C, Hamilton G, Vlahov N, Grawenda A, Haider S, Chauhan J, Buti L, Kanapin A, Lu X, Buffa F, Dianov G, von Kriegsheim A, Matallanas D, Samsonova A, Zernicka-Goetz M, O'Neill E. Papaspyropoulos A, et al. Nat Commun. 2018 Jan 30;9(1):424. doi: 10.1038/s41467-017-02786-5. Nat Commun. 2018. PMID: 29382819 Free PMC article.
RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1.
Papaspyropoulos A, Angelopoulou A, Mourkioti I, Polyzou A, Pankova D, Toskas K, Lanfredini S, Pantazaki AA, Lagopati N, Kotsinas A, Evangelou K, Chronopoulos E, O'Neill E, Gorgoulis V. Papaspyropoulos A, et al. EMBO Rep. 2022 Feb 3;23(2):e51287. doi: 10.15252/embr.202051287. Epub 2021 Dec 13. EMBO Rep. 2022. PMID: 34897944 Free PMC article.
761 results