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Page 1
Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
Nordqvist A, O'Mahony G, Fridén-Saxin M, Fredenwall M, Hogner A, Granberg KL, Aagaard A, Bäckström S, Gunnarsson A, Kaminski T, Xue Y, Dellsén A, Hansson E, Hansson P, Ivarsson I, Karlsson U, Bamberg K, Hermansson M, Georgsson J, Lindmark B, Edman K. Nordqvist A, et al. ChemMedChem. 2017 Jan 5;12(1):50-65. doi: 10.1002/cmdc.201600529. Epub 2016 Dec 15. ChemMedChem. 2017. PMID: 27897427
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
Granberg KL, Yuan ZQ, Lindmark B, Edman K, Kajanus J, Hogner A, Malmgren M, O'Mahony G, Nordqvist A, Lindberg J, Tångefjord S, Kossenjans M, Löfberg C, Brånalt J, Liu D, Selmi N, Nikitidis G, Nordberg P, Hayen A, Aagaard A, Hansson E, Hermansson M, Ivarsson I, Jansson-Löfmark R, Karlsson U, Johansson U, William-Olsson L, Hartleib-Geschwindner J, Bamberg K. Granberg KL, et al. J Med Chem. 2019 Feb 14;62(3):1385-1406. doi: 10.1021/acs.jmedchem.8b01523. Epub 2019 Jan 30. J Med Chem. 2019. PMID: 30596500
Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation.
O'Mahony G, Petersen J, Ek M, Rae R, Johansson C, Jianming L, Prokoph N, Bergström F, Bamberg K, Giordanetto F, Zarrouki B, Karlsson D, Hogner A. O'Mahony G, et al. ACS Med Chem Lett. 2022 Mar 11;13(4):681-686. doi: 10.1021/acsmedchemlett.1c00715. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450368 Free PMC article.
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.
Pallesen JS, Munier CC, Bosica F, Andrei SA, Edman K, Gunnarsson A, La Sala G, Putra OD, Srdanović S, Wilson AJ, Wissler L, Ottmann C, Perry MWD, O'Mahony G. Pallesen JS, et al. Among authors: o mahony g. J Med Chem. 2022 Dec 22;65(24):16818-16828. doi: 10.1021/acs.jmedchem.2c01635. Epub 2022 Dec 9. J Med Chem. 2022. PMID: 36484727 Free PMC article.
Identification and design of a novel series of MGAT2 inhibitors.
Barlind JG, Buckett LK, Crosby SG, Davidsson Ö, Emtenäs H, Ertan A, Jurva U, Lemurell M, Gutierrez PM, Nilsson K, O'Mahony G, Petersson AU, Redzic A, Wågberg F, Yuan ZQ. Barlind JG, et al. Bioorg Med Chem Lett. 2013 May 1;23(9):2721-6. doi: 10.1016/j.bmcl.2013.02.084. Epub 2013 Feb 27. Bioorg Med Chem Lett. 2013. PMID: 23541669
Correction to "Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction".
Pallesen JS, Munier CC, Bosica F, Andrei SA, Edman K, Gunnarsson A, La Sala G, Putra OD, Srdanović S, Wilson AJ, Wissler L, Ottmann C, Perry MWD, O'Mahony G. Pallesen JS, et al. Among authors: o mahony g. J Med Chem. 2023 Feb 9;66(3):2205-2207. doi: 10.1021/acs.jmedchem.3c00076. Epub 2023 Jan 28. J Med Chem. 2023. PMID: 36708352 Free PMC article. No abstract available.
Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors.
Giordanetto F, Knerr L, Selmi N, Llinàs A, Lindqvist A, Wang QD, Ståhlberg P, Thorstensson F, Ullah V, Nilsson K, O'Mahony G, Högberg G, Lindhardt E, Strand A, Duker G. Giordanetto F, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5557-61. doi: 10.1016/j.bmcl.2011.06.092. Epub 2011 Jun 30. Bioorg Med Chem Lett. 2011. PMID: 21782423
54 results