O'Leary BR - Search Results

1

Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity.

Gibson AR, O'Leary BR, Du J, Sarsour EH, Kalen AL, Wagner BA, Stolwijk JM, Falls-Hubert KC, Alexander MS, Carroll RS, Spitz DR, Buettner GR, Goswami PC, Cullen JJ. Gibson AR, et al. Cancer Res. 2020 Apr 1;80(7):1401-1413. doi: 10.1158/0008-5472.CAN-19-3094. Epub 2020 Feb 10. Cancer Res. 2020. PMID: 32041838 Free PMC article.

2

Hydrogen peroxide signaling mediates DHEA-induced vascular endothelial cell proliferation.

Iruthayanathan M, O'Leary B, Paul G, Dillon JS. Iruthayanathan M, et al. Steroids. 2011 Dec 11;76(13):1483-90. doi: 10.1016/j.steroids.2011.08.002. Epub 2011 Aug 16. Steroids. 2011. PMID: 21864554

3

Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.

O'Leary BR, Fath MA, Bellizzi AM, Hrabe JE, Button AM, Allen BG, Case AJ, Altekruse S, Wagner BA, Buettner GR, Lynch CF, Hernandez BY, Cozen W, Beardsley RA, Keene J, Henry MD, Domann FE, Spitz DR, Mezhir JJ. O'Leary BR, et al. Clin Cancer Res. 2015 Apr 1;21(7):1741-51. doi: 10.1158/1078-0432.CCR-14-1959. Epub 2015 Jan 29. Clin Cancer Res. 2015. PMID: 25634994 Free PMC article.

4

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.

Hrabe JE, O'Leary BR, Fath MA, Rodman SN, Button AM, Domann FE, Spitz DR, Mezhir JJ. Hrabe JE, et al. Redox Biol. 2015 Aug;5:319-327. doi: 10.1016/j.redox.2015.06.004. Epub 2015 Jun 18. Redox Biol. 2015. PMID: 26114584 Free PMC article.

5

Pharmacologic ascorbate (P-AscH^-) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma.

Wilkes JG, O'Leary BR, Du J, Klinger AR, Sibenaller ZA, Doskey CM, Gibson-Corley KN, Alexander MS, Tsai S, Buettner GR, Cullen JJ. Wilkes JG, et al. Clin Exp Metastasis. 2018 Feb;35(1-2):37-51. doi: 10.1007/s10585-018-9876-z. Epub 2018 Feb 2. Clin Exp Metastasis. 2018. PMID: 29396728 Free PMC article.

6

Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma.

O'Leary BR, Houwen FK, Johnson CL, Allen BG, Mezhir JJ, Berg DJ, Cullen JJ, Spitz DR. O'Leary BR, et al. Radiat Res. 2018 May;189(5):456-465. doi: 10.1667/RR14978.1. Epub 2018 Mar 16. Radiat Res. 2018. PMID: 29547353 Free PMC article.

7

Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer.

Alexander MS, Wilkes JG, Schroeder SR, Buettner GR, Wagner BA, Du J, Gibson-Corley K, O'Leary BR, Spitz DR, Buatti JM, Berg DJ, Bodeker KL, Vollstedt S, Brown HA, Allen BG, Cullen JJ. Alexander MS, et al. Cancer Res. 2018 Dec 15;78(24):6838-6851. doi: 10.1158/0008-5472.CAN-18-1680. Epub 2018 Sep 25. Cancer Res. 2018. PMID: 30254147 Free PMC article. Clinical Trial.

8

Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer.

Alexander MS, O'Leary BR, Wilkes JG, Gibson AR, Wagner BA, Du J, Sarsour E, Hwang RF, Buettner GR, Cullen JJ. Alexander MS, et al. Radiat Res. 2019 Jan;191(1):43-51. doi: 10.1667/RR15189.1. Epub 2018 Oct 30. Radiat Res. 2019. PMID: 30376411 Free PMC article.

9

A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells.

Alexander MS, O'Leary BR, Moose D, Du J, Henry MD, Cullen JJ. Alexander MS, et al. J Biol Methods. 2018 Sep 5;5(3):e97. doi: 10.14440/jbm.2018.250. eCollection 2018. J Biol Methods. 2018. PMID: 31453247 Free PMC article.

10

Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.

Sarsour EH, Son JM, Kalen AL, Xiao W, Du J, Alexander MS, O'Leary BR, Cullen JJ, Goswami PC. Sarsour EH, et al. J Biol Chem. 2020 May 15;295(20):6946-6957. doi: 10.1074/jbc.RA120.012798. Epub 2020 Apr 7. J Biol Chem. 2020. PMID: 32265301 Free PMC article.

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