O'Keefe S - Search Results

1

Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F.

O'Keefe S, Bhadra P, Duah KB, Zong G, Tenay L, Andrews L, Schneider H, Anderson A, Hu Z, Aljewari HS, Hall BS, Simmonds RE, Helms V, High S, Shi WQ. O'Keefe S, et al. Molecules. 2022 Jul 10;27(14):4419. doi: 10.3390/molecules27144419. Molecules. 2022. PMID: 35889292 Free PMC article.

2

Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca²⁺ Leakage from the Endoplasmic Reticulum.

Gamayun I, O'Keefe S, Pick T, Klein MC, Nguyen D, McKibbin C, Piacenti M, Williams HM, Flitsch SL, Whitehead RC, Swanton E, Helms V, High S, Zimmermann R, Cavalié A. Gamayun I, et al. Cell Chem Biol. 2019 Apr 18;26(4):571-583.e6. doi: 10.1016/j.chembiol.2019.01.010. Epub 2019 Feb 21. Cell Chem Biol. 2019. PMID: 30799222 Free PMC article.

3

Characterizing the selectivity of ER α-glucosidase inhibitors.

O'Keefe S, Roebuck QP, Nakagome I, Hirono S, Kato A, Nash R, High S. O'Keefe S, et al. Glycobiology. 2019 Jul 1;29(7):530-542. doi: 10.1093/glycob/cwz029. Glycobiology. 2019. PMID: 30976784 Free PMC article.

4

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.

Zong G, Hu Z, O'Keefe S, Tranter D, Iannotti MJ, Baron L, Hall B, Corfield K, Paatero AO, Henderson MJ, Roboti P, Zhou J, Sun X, Govindarajan M, Rohde JM, Blanchard N, Simmonds R, Inglese J, Du Y, Demangel C, High S, Paavilainen VO, Shi WQ. Zong G, et al. J Am Chem Soc. 2019 May 29;141(21):8450-8461. doi: 10.1021/jacs.8b13506. Epub 2019 May 15. J Am Chem Soc. 2019. PMID: 31059257 Free PMC article.

5

Membrane translocation at the ER: with a little help from my friends.

O'Keefe S, High S. O'Keefe S, et al. FEBS J. 2020 Nov;287(21):4607-4611. doi: 10.1111/febs.15309. Epub 2020 Apr 16. FEBS J. 2020. PMID: 32301242 Free article.

6

Eeyarestatin 24 impairs SecYEG-dependent protein trafficking and inhibits growth of clinically relevant pathogens.

Steenhuis M, Koningstein GM, Oswald J, Pick T, O'Keefe S, Koch HG, Cavalié A, Whitehead RC, Swanton E, High S, Luirink J. Steenhuis M, et al. Mol Microbiol. 2021 Jan;115(1):28-40. doi: 10.1111/mmi.14589. Epub 2020 Sep 3. Mol Microbiol. 2021. PMID: 32798330 Free PMC article.

7

Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F.

Zong G, Hu Z, Duah KB, Andrews LE, Zhou J, O'Keefe S, Whisenhunt L, Shim JS, Du Y, High S, Shi WQ. Zong G, et al. J Org Chem. 2020 Dec 18;85(24):16226-16235. doi: 10.1021/acs.joc.0c01659. Epub 2020 Dec 2. J Org Chem. 2020. PMID: 33264019 Free PMC article.

8

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor.

O'Keefe S, Roboti P, Duah KB, Zong G, Schneider H, Shi WQ, High S. O'Keefe S, et al. bioRxiv [Preprint]. 2021 Jan 5:2020.11.24.390039. doi: 10.1101/2020.11.24.390039. bioRxiv. 2021. PMID: 33269350 Free PMC article. Updated. Preprint.

9

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor.

O'Keefe S, Roboti P, Duah KB, Zong G, Schneider H, Shi WQ, High S. O'Keefe S, et al. J Cell Sci. 2021 Feb 19;134(4):jcs257758. doi: 10.1242/jcs.257758. J Cell Sci. 2021. PMID: 33468620 Free PMC article.

10

Membrane protein biogenesis at the ER: the highways and byways.

O'Keefe S, Pool MR, High S. O'Keefe S, et al. FEBS J. 2022 Nov;289(22):6835-6862. doi: 10.1111/febs.15905. Epub 2021 Jun 5. FEBS J. 2022. PMID: 33960686 Free article. Review.

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