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Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy.
Talebi A, de Laat V, Spotbeen X, Dehairs J, Rambow F, Rogiers A, Vanderhoydonc F, Rizotto L, Planque M, Doglioni G, Motamedi S, Nittner D, Roskams T, Agostinis P, Bechter O, Boecxstaens V, Garmyn M, O'Farrell M, Wagman A, Kemble G, Leucci E, Fendt SM, Marine JC, Swinnen JV. Talebi A, et al. Among authors: o farrell m. J Exp Clin Cancer Res. 2023 Apr 19;42(1):92. doi: 10.1186/s13046-023-02664-7. J Exp Clin Cancer Res. 2023. PMID: 37072838 Free PMC article.
First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors.
Falchook G, Infante J, Arkenau HT, Patel MR, Dean E, Borazanci E, Brenner A, Cook N, Lopez J, Pant S, Frankel A, Schmid P, Moore K, McCulloch W, Grimmer K, O'Farrell M, Kemble G, Burris H. Falchook G, et al. EClinicalMedicine. 2021 Mar 30;34:100797. doi: 10.1016/j.eclinm.2021.100797. eCollection 2021 Apr. EClinicalMedicine. 2021. PMID: 33870151 Free PMC article.
TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial.
Loomba R, Mohseni R, Lucas KJ, Gutierrez JA, Perry RG, Trotter JF, Rahimi RS, Harrison SA, Ajmera V, Wayne JD, O'Farrell M, McCulloch W, Grimmer K, Rinella M, Wai-Sun Wong V, Ratziu V, Gores GJ, Neuschwander-Tetri BA, Kemble G. Loomba R, et al. Among authors: o farrell m. Gastroenterology. 2021 Nov;161(5):1475-1486. doi: 10.1053/j.gastro.2021.07.025. Epub 2021 Jul 23. Gastroenterology. 2021. PMID: 34310978 Free article. Clinical Trial.
Therapeutic efficacy of FASN inhibition in preclinical models of HCC.
Wang H, Zhou Y, Xu H, Wang X, Zhang Y, Shang R, O'Farrell M, Roessler S, Sticht C, Stahl A, Evert M, Calvisi DF, Zeng Y, Chen X. Wang H, et al. Among authors: o farrell m. Hepatology. 2022 Oct;76(4):951-966. doi: 10.1002/hep.32359. Epub 2022 Feb 16. Hepatology. 2022. PMID: 35076948 Free PMC article.
Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use.
Worthmann A, Ridder J, Piel SYL, Evangelakos I, Musfeldt M, Voß H, O'Farrell M, Fischer AW, Adak S, Sundd M, Siffeti H, Haumann F, Kloth K, Bierhals T, Heine M, Pertzborn P, Pauly M, Scholz JJ, Kundu S, Fuh MM, Neu A, Tödter K, Hempel M, Knippschild U, Semenkovich CF, Schlüter H, Heeren J, Scheja L, Kubisch C, Schlein C. Worthmann A, et al. Among authors: o farrell m. Nat Commun. 2024 Jan 2;15(1):45. doi: 10.1038/s41467-023-44364-y. Nat Commun. 2024. PMID: 38167725 Free PMC article.
Inter seasonal validation of non-contact NIR spectroscopy for measurement of total soluble solids in high tunnel strawberries.
Petter Wold J, Vejle Andersen P, Aaby K, Fagertun Remberg S, Hansen A, O'Farrell M, Tschudi J. Petter Wold J, et al. Among authors: o farrell m. Spectrochim Acta A Mol Biomol Spectrosc. 2024 Mar 15;309:123853. doi: 10.1016/j.saa.2024.123853. Epub 2024 Jan 10. Spectrochim Acta A Mol Biomol Spectrosc. 2024. PMID: 38217993 Free article.
The earliest unambiguous Neanderthal engravings on cave walls: La Roche-Cotard, Loire Valley, France.
Marquet JC, Freiesleben TH, Thomsen KJ, Murray AS, Calligaro M, Macaire JJ, Robert E, Lorblanchet M, Aubry T, Bayle G, Bréhéret JG, Camus H, Chareille P, Egels Y, Guillaud É, Guérin G, Gautret P, Liard M, O'Farrell M, Peyrouse JB, Thamó-Bozsó E, Verdin P, Wojtczak D, Oberlin C, Jaubert J. Marquet JC, et al. Among authors: o farrell m. PLoS One. 2023 Jun 21;18(6):e0286568. doi: 10.1371/journal.pone.0286568. eCollection 2023. PLoS One. 2023. PMID: 37343032 Free PMC article.
70 results