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Page 1
Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans.
Rijal P, Elias SC, Machado SR, Xiao J, Schimanski L, O'Dowd V, Baker T, Barry E, Mendelsohn SC, Cherry CJ, Jin J, Labbé GM, Donnellan FR, Rampling T, Dowall S, Rayner E, Findlay-Wilson S, Carroll M, Guo J, Xu XN, Huang KA, Takada A, Burgess G, McMillan D, Popplewell A, Lightwood DJ, Draper SJ, Townsend AR. Rijal P, et al. Among authors: o dowd v. Cell Rep. 2019 Apr 2;27(1):172-186.e7. doi: 10.1016/j.celrep.2019.03.020. Cell Rep. 2019. PMID: 30943399 Free article. Clinical Trial.
In vitro and in vivo characterisation of anti-murine IL-13 antibodies recognising distinct functional epitopes.
Berry LM, Adams R, Airey M, Bracher MG, Bourne T, Carrington B, Cross AS, Davies GC, Finney HM, Foulkes R, Gozzard N, Griffin RA, Hailu H, Lamour SD, Lawson AD, Lightwood DJ, McKnight AJ, O'Dowd VL, Oxbrow AK, Popplewell AG, Shaw S, Stephens PE, Sweeney B, Tomlinson KL, Uhe C, Palframan RT. Berry LM, et al. Int Immunopharmacol. 2009 Feb;9(2):201-6. doi: 10.1016/j.intimp.2008.11.001. Epub 2008 Nov 27. Int Immunopharmacol. 2009. PMID: 19041426
The discovery, engineering and characterisation of a highly potent anti-human IL-13 fab fragment designed for administration by inhalation.
Lightwood D, O'Dowd V, Carrington B, Veverka V, Carr MD, Tservistas M, Henry AJ, Smith B, Tyson K, Lamour S, Bracher M, Sarkar K, Turner A, Lawson AD, Bourne T, Gozzard N, Palframan R. Lightwood D, et al. Among authors: o dowd v. J Mol Biol. 2013 Feb 8;425(3):577-93. doi: 10.1016/j.jmb.2012.11.036. Epub 2012 Dec 3. J Mol Biol. 2013. PMID: 23219467
A mixture of functionally oligoclonal humanized monoclonal antibodies that neutralize Clostridium difficile TcdA and TcdB with high levels of in vitro potency shows in vivo protection in a hamster infection model.
Davies NL, Compson JE, Mackenzie B, O'Dowd VL, Oxbrow AK, Heads JT, Turner A, Sarkar K, Dugdale SL, Jairaj M, Christodoulou L, Knight DE, Cross AS, Hervé KJ, Tyson KL, Hailu H, Doyle CB, Ellis M, Kriek M, Cox M, Page MJ, Moore AR, Lightwood DJ, Humphreys DP. Davies NL, et al. Among authors: o dowd vl. Clin Vaccine Immunol. 2013 Mar;20(3):377-90. doi: 10.1128/CVI.00625-12. Epub 2013 Jan 16. Clin Vaccine Immunol. 2013. PMID: 23324518 Free PMC article.
The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method.
Clargo AM, Hudson AR, Ndlovu W, Wootton RJ, Cremin LA, O'Dowd VL, Nowosad CR, Starkie DO, Shaw SP, Compson JE, White DP, MacKenzie B, Snowden JR, Newnham LE, Wright M, Stephens PE, Griffiths MR, Lawson AD, Lightwood DJ. Clargo AM, et al. Among authors: o dowd vl. MAbs. 2014 Jan-Feb;6(1):143-59. doi: 10.4161/mabs.27044. MAbs. 2014. PMID: 24423622 Free PMC article.
Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell-Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis.
Steen J, Forsström B, Sahlström P, Odowd V, Israelsson L, Krishnamurthy A, Badreh S, Mathsson Alm L, Compson J, Ramsköld D, Ndlovu W, Rapecki S, Hansson M, Titcombe PJ, Bang H, Mueller DL, Catrina AI, Grönwall C, Skriner K, Nilsson P, Lightwood D, Klareskog L, Malmström V. Steen J, et al. Arthritis Rheumatol. 2019 Feb;71(2):196-209. doi: 10.1002/art.40699. Arthritis Rheumatol. 2019. PMID: 30152202 Free PMC article.
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms.
Ramberger M, Berretta A, Tan JMM, Sun B, Michael S, Yeo T, Theorell J, Bashford-Rogers R, Paneva S, O'Dowd V, Dedi N, Topia S, Griffin R, Ramirez-Franco J, El Far O, Baulac S, Leite MI, Sen A, Jeans A, McMillan D, Marshall D, Anthony D, Lightwood D, Waters P, Irani SR. Ramberger M, et al. Among authors: o dowd v. Brain. 2020 Jun 1;143(6):1731-1745. doi: 10.1093/brain/awaa104. Brain. 2020. PMID: 32437528 Free PMC article.
CD1a promotes systemic manifestations of skin inflammation.
Hardman CS, Chen YL, Wegrecki M, Ng SW, Murren R, Mangat D, Silva JP, Munro R, Chan WY, O'Dowd V, Doyle C, Mori P, Popplewell A, Rossjohn J, Lightwood D, Ogg GS. Hardman CS, et al. Among authors: o dowd v. Nat Commun. 2022 Dec 7;13(1):7535. doi: 10.1038/s41467-022-35071-1. Nat Commun. 2022. PMID: 36477177 Free PMC article.
Corrigendum to "The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation" [J. Mol. Biol. 425 (2013), 577-593].
Lightwood D, O'Dowd V, Carrington B, Veverka V, Carr MD, Tservistas M, Henry AJ, Smith B, Tyson K, Lamour S, Bracher M, Sarkar K, Turner A, Lawson AD, Bourne T, Gozzard N, Palframan R. Lightwood D, et al. Among authors: o dowd v. J Mol Biol. 2013 Jun 12;425(11):2082. doi: 10.1016/j.jmb.2013.03.038. Epub 2013 Apr 5. J Mol Biol. 2013. PMID: 29890570 No abstract available.
13 results