O'Dowd CR - Search Results

1

Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors.

O'Dowd CR, Helm MD, Rountree JSS, Flasz JT, Arkoudis E, Miel H, Hewitt PR, Jordan L, Barker O, Hughes C, Rozycka E, Cassidy E, McClelland K, Odrzywol E, Page N, Feutren-Burton S, Dvorkin S, Gavory G, Harrison T. O'Dowd CR, et al. ACS Med Chem Lett. 2018 Feb 21;9(3):238-243. doi: 10.1021/acsmedchemlett.7b00512. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541367 Free PMC article.

2

Growth inhibitory activity of extracted material and isolated compounds from the fruits of Kigelia pinnata.

Higgins CA, Bell T, Delbederi Z, Feutren-Burton S, McClean B, O'Dowd C, Watters W, Armstrong P, Waugh D, van den Berg H. Higgins CA, et al. Planta Med. 2010 Nov;76(16):1840-6. doi: 10.1055/s-0030-1250046. Epub 2010 Jun 17. Planta Med. 2010. PMID: 20560113

3

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.

Gavory G, O'Dowd CR, Helm MD, Flasz J, Arkoudis E, Dossang A, Hughes C, Cassidy E, McClelland K, Odrzywol E, Page N, Barker O, Miel H, Harrison T. Gavory G, et al. Among authors: o dowd cr. Nat Chem Biol. 2018 Feb;14(2):118-125. doi: 10.1038/nchembio.2528. Epub 2017 Dec 4. Nat Chem Biol. 2018. PMID: 29200206

4

Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development.

Page N, Wappett M, O'Dowd CR, O'Rourke M, Gavory G, Zhang L, Rountree JSS, Jordan L, Barker O, Gibson H, Boyd C, Feutren-Burton S, McLean E, Trevitt G, Harrison T. Page N, et al. Among authors: o dowd cr. Sci Rep. 2022 Sep 20;12(1):15715. doi: 10.1038/s41598-022-20208-5. Sci Rep. 2022. PMID: 36127435 Free PMC article.

5

USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF.

Jurisic A, Sung PJ, Wappett M, Daubriac J, Lobb IT, Kung WW, Crawford N, Page N, Cassidy E, Feutren-Burton S, Rountree JSS, Helm MD, O'Dowd CR, Kennedy RD, Gavory G, Cranston AN, Longley DB, Jacq X, Harrison T. Jurisic A, et al. Among authors: o dowd cr. Clin Transl Med. 2024 Apr;14(4):e1648. doi: 10.1002/ctm2.1648. Clin Transl Med. 2024. PMID: 38602256 Free PMC article.

6

Chemoenzymatic synthesis of carbasugars (+)-pericosines A-C from diverse aromatic cis-dihydrodiol precursors.

Boyd DR, Sharma ND, Acaru CA, Malone JF, O'Dowd CR, Allen CC, Stevenson PJ. Boyd DR, et al. Among authors: o dowd cr. Org Lett. 2010 May 21;12(10):2206-9. doi: 10.1021/ol100525r. Org Lett. 2010. PMID: 20411952

7

Chemoenzymatic synthesis of carbasugars from iodobenzene.

Boyd DR, Sharma ND, Llamas NM, Malone JF, O'Dowd CR, Allen CC. Boyd DR, et al. Among authors: o dowd cr. Org Biomol Chem. 2005 May 21;3(10):1953-63. doi: 10.1039/b502009c. Epub 2005 Apr 18. Org Biomol Chem. 2005. PMID: 15889179

8

cis-Dihydrodiol, arene oxide and phenol metabolites of dictamnine: key intermediates in the biodegradation and biosynthesis of furoquinoline alkaloids.

Boyd DR, Sharma ND, O'Dowd CR, Carroll JG, Loke PL, Allen CC. Boyd DR, et al. Among authors: o dowd cr. Chem Commun (Camb). 2005 Aug 21;(31):3989-91. doi: 10.1039/b506944k. Epub 2005 Jul 11. Chem Commun (Camb). 2005. PMID: 16075095

9

Chemoenzymatic synthesis of the trans-dihydrodiol isomers of monosubstituted benzenes via anti-benzene dioxides.

Boyd DR, Sharma ND, Llamas NM, O'Dowd CR, Allen CC. Boyd DR, et al. Among authors: o dowd cr. Org Biomol Chem. 2006 Jun 7;4(11):2208-17. doi: 10.1039/b603928f. Epub 2006 May 2. Org Biomol Chem. 2006. PMID: 16729130

10

syn-Benzene dioxides: chemoenzymatic synthesis from 2,3-cis-dihydrodiol derivatives of monosubstituted benzenes and their application in the synthesis of regioisomeric 1,2- and 3,4-cis-dihydrodiols and 1,4-dioxocins.

Boyd DR, Sharma ND, Llamas NM, O'Dowd CR, Allen CC. Boyd DR, et al. Among authors: o dowd cr. Org Biomol Chem. 2007 Jul 21;5(14):2267-73. doi: 10.1039/b704584k. Epub 2007 Jun 12. Org Biomol Chem. 2007. PMID: 17609758

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