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The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture.
Borda V, Alvim I, Mendes M, Silva-Carvalho C, Soares-Souza GB, Leal TP, Furlan V, Scliar MO, Zamudio R, Zolini C, Araújo GS, Luizon MR, Padilla C, Cáceres O, Levano K, Sánchez C, Trujillo O, Flores-Villanueva PO, Dean M, Fuselli S, Machado M, Romero PE, Tassi F, Yeager M, O'Connor TD, Gilman RH, Tarazona-Santos E, Guio H. Borda V, et al. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32557-32565. doi: 10.1073/pnas.2013773117. Epub 2020 Dec 4. Proc Natl Acad Sci U S A. 2020. PMID: 33277433 Free PMC article.
Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire.
Harris DN, Song W, Shetty AC, Levano KS, Cáceres O, Padilla C, Borda V, Tarazona D, Trujillo O, Sanchez C, Kessler MD, Galarza M, Capristano S, Montejo H, Flores-Villanueva PO, Tarazona-Santos E, O'Connor TD, Guio H. Harris DN, et al. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6526-E6535. doi: 10.1073/pnas.1720798115. Epub 2018 Jun 26. Proc Natl Acad Sci U S A. 2018. PMID: 29946025 Free PMC article.
A positively selected FBN1 missense variant reduces height in Peruvian individuals.
Asgari S, Luo Y, Akbari A, Belbin GM, Li X, Harris DN, Selig M, Bartell E, Calderon R, Slowikowski K, Contreras C, Yataco R, Galea JT, Jimenez J, Coit JM, Farroñay C, Nazarian RM, O'Connor TD, Dietz HC, Hirschhorn JN, Guio H, Lecca L, Kenny EE, Freeman EE, Murray MB, Raychaudhuri S. Asgari S, et al. Nature. 2020 Jun;582(7811):234-239. doi: 10.1038/s41586-020-2302-0. Epub 2020 May 13. Nature. 2020. PMID: 32499652 Free PMC article.
Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.
Scliar MO, Sant'Anna HP, Santolalla ML, Leal TP, Araújo NM, Alvim I, Borda V, Magalhães WCS, Gouveia MH, Lyra R, Machado M, Michelin L, Rodrigues MR, Araújo GS, Kehdy FSG, Zolini C, Peixoto SV, Luizon MR, Lobo F, Naslavsky MS, Yamamoto GL, Duarte YAO, Hansen MEB, Norris SA, Gilman RH, Guio H, Hsing AW, Mbulaiteye SM, Mensah J, Dutil J, Yeager M, Yeboah E, Tishkoff SA, Choudhury A, Ramsay M, Passos-Bueno MR, Zatz M, O Connor TD, Pereira AC, Barreto ML, Lima-Costa MF, Horta BL, Tarazona-Santos E. Scliar MO, et al. Int J Obes (Lond). 2021 May;45(5):1017-1029. doi: 10.1038/s41366-021-00761-1. Epub 2021 Feb 26. Int J Obes (Lond). 2021. PMID: 33633342 Free PMC article.
Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans.
Kehdy FSG, Pita-Oliveira M, Scudeler MM, Torres-Loureiro S, Zolini C, Moreira R, Michelin LA, Alvim I, Silva-Carvalho C, Furlan VC, Aquino MM, Santolalla ML, Borda V, Soares-Souza GB, Jaramillo-Valverde L, Vasquez-Dominguez A, Neira CS, Aguiar RS, Verdugo RA, O Connor TD, Guio H, Tarazona-Santos E, Leal TP, Rodrigues-Soares F. Kehdy FSG, et al. Genet Mol Biol. 2021 Aug 25;44(1 Suppl 1):e20200484. doi: 10.1590/1678-4685-GMB-2020-0484. eCollection 2021. Genet Mol Biol. 2021. PMID: 34436507 Free PMC article.
Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas.
Guimarães Alves AC, Sukow NM, Adelman Cipolla G, Mendes M, Leal TP, Petzl-Erler ML, Lehtonen Rodrigues Souza R, Rainha de Souza I, Sanchez C, Santolalla M, Loesch D, Dean M, Machado M, Moon JY, Kaplan R, North KE, Weiss S, Barreto ML, Lima-Costa MF, Guio H, Cáceres O, Padilla C, Tarazona-Santos E, Mata IF, Dieguez E, Raggio V, Lescano A, Tumas V, Borges V, Ferraz HB, Rieder CR, Schumacher-Schuh A, Santos-Lobato BL, Chana-Cuevas P, Fernandez W, Arboleda G, Arboleda H, Arboleda-Bustos CE, O'Connor TD, Beltrame MH, Borda V. Guimarães Alves AC, et al. Front Genet. 2021 Sep 22;12:671079. doi: 10.3389/fgene.2021.671079. eCollection 2021. Front Genet. 2021. PMID: 34630506 Free PMC article.
Population genetics of PDE4B (phosphodiesterase-4B) in neglected Native Americans: Implications for cancer pharmacogenetics.
Moreira RG, Saraiva-Duarte JM, Pereira AC, Sosa-Macias M, Galaviz-Hernandez C, Santolalla ML, Magalhães WCS, Zolini C, Leal TP, Balázs Z, Llerena A, Gilman RH, Mill JG, Borda V, Guio H, O'Connor TD, Tarazona-Santos E, Rodrigues-Soares F. Moreira RG, et al. Clin Transl Sci. 2022 Jun;15(6):1400-1405. doi: 10.1111/cts.13266. Epub 2022 Mar 28. Clin Transl Sci. 2022. PMID: 35266293 Free PMC article.
73 results