O'Connell S - Search Results

1

Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free-Wilson Analysis for Improved In Vivo Efficacy.

Murphy ST, Atienza J, Brown JW, Cheruvallath ZS, Cukierski MJ, Fabrey R, Keung W, Kwok L, O'Connell S, Tang M, Vanderpool DL, Vincent PW, Zhang L, Marx MA. Murphy ST, et al. ACS Med Chem Lett. 2023 Oct 25;14(11):1544-1550. doi: 10.1021/acsmedchemlett.3c00351. eCollection 2023 Nov 9. ACS Med Chem Lett. 2023. PMID: 37970587 Free PMC article.

2

Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity.

Bressi JC, de Jong R, Wu Y, Jennings AJ, Brown JW, O'Connell S, Tari LW, Skene RJ, Vu P, Navre M, Cao X, Gangloff AR. Bressi JC, et al. Bioorg Med Chem Lett. 2010 May 15;20(10):3138-41. doi: 10.1016/j.bmcl.2010.03.092. Epub 2010 Mar 30. Bioorg Med Chem Lett. 2010. PMID: 20392637

3

Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.

Wallace MB, Adams ME, Kanouni T, Mol CD, Dougan DR, Feher VA, O'Connell SM, Shi L, Halkowycz P, Dong Q. Wallace MB, et al. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4156-8. doi: 10.1016/j.bmcl.2010.05.058. Epub 2010 May 20. Bioorg Med Chem Lett. 2010. PMID: 20621728

4

Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.

Dong Q, Dougan DR, Gong X, Halkowycz P, Jin B, Kanouni T, O'Connell SM, Scorah N, Shi L, Wallace MB, Zhou F. Dong Q, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1315-9. doi: 10.1016/j.bmcl.2011.01.071. Epub 2011 Jan 22. Bioorg Med Chem Lett. 2011. PMID: 21310613

5

Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy.

Adams ME, Wallace MB, Kanouni T, Scorah N, O'Connell SM, Miyake H, Shi L, Halkowycz P, Zhang L, Dong Q. Adams ME, et al. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2411-4. doi: 10.1016/j.bmcl.2012.02.026. Epub 2012 Feb 20. Bioorg Med Chem Lett. 2012. PMID: 22406151

6

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors.

Gangloff AR, Brown J, de Jong R, Dougan DR, Grimshaw CE, Hixon M, Jennings A, Kamran R, Kiryanov A, O'Connell S, Taylor E, Vu P. Gangloff AR, et al. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4501-5. doi: 10.1016/j.bmcl.2013.06.055. Epub 2013 Jun 24. Bioorg Med Chem Lett. 2013. PMID: 23850199

7

Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants.

Micel LN, Tentler JJ, Tan AC, Selby HM, Brunkow KL, Robertson KM, Davis SL, Klauck PJ, Pitts TM, Gangolli E, Fabrey R, O'Connell SM, Vincent PW, Eckhardt SG. Micel LN, et al. Mol Cancer Ther. 2015 Feb;14(2):317-25. doi: 10.1158/1535-7163.MCT-13-1012. Epub 2014 Nov 5. Mol Cancer Ther. 2015. PMID: 25376610 Free PMC article.

8

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.

Chen YK, Bonaldi T, Cuomo A, Del Rosario JR, Hosfield DJ, Kanouni T, Kao SC, Lai C, Lobo NA, Matuszkiewicz J, McGeehan A, O'Connell SM, Shi L, Stafford JA, Stansfield RK, Veal JM, Weiss MS, Yuen NY, Wallace MB. Chen YK, et al. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874. doi: 10.1021/acsmedchemlett.7b00220. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835804 Free PMC article.

9

Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors.

Bennett MJ, Wu Y, Boloor A, Matuszkiewicz J, O'Connell SM, Shi L, Stansfield RK, Del Rosario JR, Veal JM, Hosfield DJ, Xu J, Kaldor SW, Stafford JA, Betancort JM. Bennett MJ, et al. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1811-1816. doi: 10.1016/j.bmcl.2018.04.016. Epub 2018 Apr 10. Bioorg Med Chem Lett. 2018. PMID: 29657099

10

Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).

Kanouni T, Severin C, Cho RW, Yuen NY, Xu J, Shi L, Lai C, Del Rosario JR, Stansfield RK, Lawton LN, Hosfield D, O'Connell S, Kreilein MM, Tavares-Greco P, Nie Z, Kaldor SW, Veal JM, Stafford JA, Chen YK. Kanouni T, et al. J Med Chem. 2020 Dec 10;63(23):14522-14529. doi: 10.1021/acs.jmedchem.0c00978. Epub 2020 Oct 9. J Med Chem. 2020. PMID: 33034194

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