O'Connell JF - Search Results

1

Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase.

Howe AY, Bloom J, Baldick CJ, Benetatos CA, Cheng H, Christensen JS, Chunduru SK, Coburn GA, Feld B, Gopalsamy A, Gorczyca WP, Herrmann S, Johann S, Jiang X, Kimberland ML, Krisnamurthy G, Olson M, Orlowski M, Swanberg S, Thompson I, Thorn M, Del Vecchio A, Young DC, van Zeijl M, Ellingboe JW, Upeslacis J, Collett M, Mansour TS, O'Connell JF. Howe AY, et al. Antimicrob Agents Chemother. 2004 Dec;48(12):4813-21. doi: 10.1128/AAC.48.12.4813-4821.2004. Antimicrob Agents Chemother. 2004. PMID: 15561861 Free PMC article.

2

Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.

Gopalsamy A, Lim K, Ciszewski G, Park K, Ellingboe JW, Bloom J, Insaf S, Upeslacis J, Mansour TS, Krishnamurthy G, Damarla M, Pyatski Y, Ho D, Howe AY, Orlowski M, Feld B, O'Connell J. Gopalsamy A, et al. J Med Chem. 2004 Dec 16;47(26):6603-8. doi: 10.1021/jm0401255. J Med Chem. 2004. PMID: 15588095

3

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.

Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Gopalsamy A, et al. J Med Chem. 2006 Jun 1;49(11):3052-5. doi: 10.1021/jm060168g. J Med Chem. 2006. PMID: 16722622

4

Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor.

Howe AY, Cheng H, Thompson I, Chunduru SK, Herrmann S, O'Connell J, Agarwal A, Chopra R, Del Vecchio AM. Howe AY, et al. Antimicrob Agents Chemother. 2006 Dec;50(12):4103-13. doi: 10.1128/AAC.00365-06. Epub 2006 Aug 28. Antimicrob Agents Chemother. 2006. PMID: 16940072 Free PMC article.

5

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.

Nittoli T, Curran K, Insaf S, DiGrandi M, Orlowski M, Chopra R, Agarwal A, Howe AY, Prashad A, Floyd MB, Johnson B, Sutherland A, Wheless K, Feld B, O'Connell J, Mansour TS, Bloom J. Nittoli T, et al. J Med Chem. 2007 May 3;50(9):2108-16. doi: 10.1021/jm061428x. Epub 2007 Apr 3. J Med Chem. 2007. PMID: 17402724

6

Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.

Howe AY, Cheng H, Johann S, Mullen S, Chunduru SK, Young DC, Bard J, Chopra R, Krishnamurthy G, Mansour T, O'Connell J. Howe AY, et al. Antimicrob Agents Chemother. 2008 Sep;52(9):3327-38. doi: 10.1128/AAC.00238-08. Epub 2008 Jun 16. Antimicrob Agents Chemother. 2008. PMID: 18559648 Free PMC article.

7

Specific inhibition of human cytomegalovirus glycoprotein B-mediated fusion by a novel thiourea small molecule.

Jones TR, Lee SW, Johann SV, Razinkov V, Visalli RJ, Feld B, Bloom JD, O'Connell J. Jones TR, et al. J Virol. 2004 Feb;78(3):1289-300. doi: 10.1128/jvi.78.3.1289-1300.2004. J Virol. 2004. PMID: 14722284 Free PMC article.

8

In vitro and in vivo activities of novel 6-methylidene penems as beta-lactamase inhibitors.

Weiss WJ, Petersen PJ, Murphy TM, Tardio L, Yang Y, Bradford PA, Venkatesan AM, Abe T, Isoda T, Mihira A, Ushirogochi H, Takasake T, Projan S, O'Connell J, Mansour TS. Weiss WJ, et al. Antimicrob Agents Chemother. 2004 Dec;48(12):4589-96. doi: 10.1128/AAC.48.12.4589-4596.2004. Antimicrob Agents Chemother. 2004. PMID: 15561830 Free PMC article.

9

Elongation of synthetic RNA templates by hepatitis C virus NS5B polymerase.

Liu C, Chopra R, Swanberg S, Olland S, O'Connell J, Herrmann S. Liu C, et al. J Biol Chem. 2004 Mar 12;279(11):10738-46. doi: 10.1074/jbc.M310062200. Epub 2003 Dec 19. J Biol Chem. 2004. PMID: 14688285 Free article.

10

RFI-641, a potent respiratory syncytial virus inhibitor.

Huntley CC, Weiss WJ, Gazumyan A, Buklan A, Feld B, Hu W, Jones TR, Murphy T, Nikitenko AA, O'Hara B, Prince G, Quartuccio S, Raifeld YE, Wyde P, O'Connell JF. Huntley CC, et al. Antimicrob Agents Chemother. 2002 Mar;46(3):841-7. doi: 10.1128/AAC.46.3.841-847.2002. Antimicrob Agents Chemother. 2002. PMID: 11850270 Free PMC article.

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