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Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines.
Moudio S, Willis A, Pytka K, Abulkassim R, Brett RR, Webster JF, Wozny C, Barbour M, Jiang HR, Watson DG, van Kralingen JC, MacKenzie SM, Daniels M, McColl BW, Sossick S, Nuthall HN, Bushell TJ. Moudio S, et al. Among authors: nuthall hn. Psychopharmacology (Berl). 2022 Jan;239(1):229-242. doi: 10.1007/s00213-021-06040-1. Epub 2021 Dec 9. Psychopharmacology (Berl). 2022. PMID: 34888704 Free PMC article.
Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration.
Obst J, Simon E, Martin-Estebane M, Pipi E, Barkwill LM, Gonzalez-Rivera I, Buchanan F, Prescott AR, Faust D, Fox S, Brownlees J, Taylor D, Perry VH, Nuthall H, Atkinson PJ, Karran E, Routledge C, Gomez-Nicola D. Obst J, et al. Front Immunol. 2020 Oct 8;11:579000. doi: 10.3389/fimmu.2020.579000. eCollection 2020. Front Immunol. 2020. PMID: 33162994 Free PMC article.
Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.
Keatinge M, Bui H, Menke A, Chen YC, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M, Trollope L, Payne T, McTighe A, Mortiboys H, de Jager S, Nuthall H, Kuo MS, Fleming A, Schapira AH, Renshaw SA, Highley JR, Chacinska A, Panula P, Burton EA, O'Neill MJ, Bandmann O. Keatinge M, et al. Hum Mol Genet. 2015 Dec 1;24(23):6640-52. doi: 10.1093/hmg/ddv369. Epub 2015 Sep 16. Hum Mol Genet. 2015. PMID: 26376862 Free PMC article.
PET ligands [18F]LSN3316612 and [11C]LSN3316612 quantify O-linked-β-N-acetyl-glucosamine hydrolase in the brain.
Lu S, Haskali MB, Ruley KM, Dreyfus NJ, DuBois SL, Paul S, Liow JS, Morse CL, Kowalski A, Gladding RL, Gilmore J, Mogg AJ, Morin SM, Lindsay-Scott PJ, Ruble JC, Kant NA, Shcherbinin S, Barth VN, Johnson MP, Cuadrado M, Jambrina E, Mannes AJ, Nuthall HN, Zoghbi SS, Jesudason CD, Innis RB, Pike VW. Lu S, et al. Among authors: nuthall hn. Sci Transl Med. 2020 May 13;12(543):eaau2939. doi: 10.1126/scitranslmed.aau2939. Sci Transl Med. 2020. PMID: 32404505 Free PMC article.
PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers.
Lee JH, Liow JS, Paul S, Morse CL, Haskali MB, Manly L, Shcherbinin S, Ruble JC, Kant N, Collins EC, Nuthall HN, Zanotti-Fregonara P, Zoghbi SS, Pike VW, Innis RB. Lee JH, et al. Among authors: nuthall hn. EJNMMI Res. 2020 Mar 14;10(1):20. doi: 10.1186/s13550-020-0616-4. EJNMMI Res. 2020. PMID: 32172476 Free PMC article.
Evaluation of a PET Radioligand to Image O-GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse.
Paul S, Haskali MB, Liow JS, Zoghbi SS, Barth VN, Kolodrubetz MC, Bond MR, Morse CL, Gladding RL, Frankland MP, Kant N, Slieker L, Shcherbinin S, Nuthall HN, Zanotti-Fregonara P, Hanover JA, Jesudason C, Pike VW, Innis RB. Paul S, et al. Among authors: nuthall hn. J Nucl Med. 2019 Jan;60(1):129-134. doi: 10.2967/jnumed.118.213231. Epub 2018 Sep 13. J Nucl Med. 2019. PMID: 30213846 Free PMC article.
20 results