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Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies.
Muecksch F, Weisblum Y, Barnes CO, Schmidt F, Schaefer-Babajew D, Lorenzi JCC, Flyak AI, DeLaitsch AT, Huey-Tubman KE, Hou S, Schiffer CA, Gaebler C, Wang Z, Da Silva J, Poston D, Finkin S, Cho A, Cipolla M, Oliveira TY, Millard KG, Ramos V, Gazumyan A, Rutkowska M, Caskey M, Nussenzweig MC, Bjorkman PJ, Hatziioannou T, Bieniasz PD. Muecksch F, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2021 Mar 8:2021.03.07.434227. doi: 10.1101/2021.03.07.434227. bioRxiv. 2021. PMID: 33758864 Free PMC article. Updated. Preprint.
Naturally enhanced neutralizing breadth to SARS-CoV-2 after one year.
Wang Z, Muecksch F, Schaefer-Babajew D, Finkin S, Viant C, Gaebler C, Hoffmann HH, Barnes CO, Cipolla M, Ramos V, Oliveira TY, Cho A, Schmidt F, da Silva J, Bednarski E, Aguado L, Yee J, Daga M, Turroja M, Millard KG, Jankovic M, Gazumyan A, Zhao Z, Rice CM, Bieniasz PD, Caskey M, Hatziioannou T, Nussenzweig MC. Wang Z, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2021 Jun 2:2021.05.07.443175. doi: 10.1101/2021.05.07.443175. bioRxiv. 2021. PMID: 34100013 Free PMC article. Updated. Preprint.
Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins.
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Tanfous TB, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC. Wang Z, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2022 Feb 1:2022.02.01.478695. doi: 10.1101/2022.02.01.478695. bioRxiv. 2022. PMID: 35132412 Free PMC article. Updated. Preprint.
Increased Potency and Breadth of SARS-CoV-2 Neutralizing Antibodies After a Third mRNA Vaccine Dose.
Muecksch F, Wang Z, Cho A, Gaebler C, Tanfous TB, DaSilva J, Bednarski E, Ramos V, Zong S, Johnson B, Raspe R, Schaefer-Babajew D, Shimeliovich I, Daga M, Yao KH, Schmidt F, Millard KG, Turroja M, Jankovic M, Oliveria TY, Gazumyan A, Caskey M, Hatziioannou T, Bieniasz PD, Nussenzweig MC. Muecksch F, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2022 Feb 15:2022.02.14.480394. doi: 10.1101/2022.02.14.480394. bioRxiv. 2022. PMID: 35194607 Free PMC article. Preprint.
Continuous germinal center invasion contributes to the diversity of the immune response.
Hägglöf T, Cipolla M, Loewe M, Chen ST, Mesin L, Hartweger H, ElTanbouly MA, Cho A, Gazumyan A, Ramos V, Stamatatos L, Oliveira TY, Nussenzweig MC, Viant C. Hägglöf T, et al. Among authors: nussenzweig mc. Cell. 2023 Jan 5;186(1):147-161.e15. doi: 10.1016/j.cell.2022.11.032. Epub 2022 Dec 23. Cell. 2023. PMID: 36565698 Free PMC article.
SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity.
Zhang F, Schmidt F, Muecksch F, Wang Z, Gazumyan A, Nussenzweig MC, Gaebler C, Caskey M, Hatziioannou T, Bieniasz PD. Zhang F, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2023 Jun 30:2023.06.30.547241. doi: 10.1101/2023.06.30.547241. bioRxiv. 2023. PMID: 37425700 Free PMC article. Updated. Preprint.
Heteromultimeric sarbecovirus receptor binding domain immunogens primarily generate variant-specific neutralizing antibodies.
Zang T, Osei Kuffour E, Baharani VA, Canis M, Schmidt F, Da Silva J, Lercher A, Chaudhary P, Hoffmann HH, Gazumyan A, Miranda IC, MacDonald MR, Rice CM, Nussenzweig MC, Hatziioannou T, Bieniasz PD. Zang T, et al. Among authors: nussenzweig mc. Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2317367120. doi: 10.1073/pnas.2317367120. Epub 2023 Dec 14. Proc Natl Acad Sci U S A. 2023. PMID: 38096415 Free PMC article.
Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain.
Yang L, Van Beek M, Wang Z, Muecksch F, Canis M, Hatziioannou T, Bieniasz PD, Nussenzweig MC, Chakraborty AK. Yang L, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2022 Aug 25:2022.08.24.505127. doi: 10.1101/2022.08.24.505127. bioRxiv. 2022. PMID: 36052368 Free PMC article. Updated. Preprint.
467 results