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Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women.
Panknin O, Wagenfeld A, Bone W, Bender E, Nowak-Reppel K, Fernández-Montalván AE, Nubbemeyer R, Bäurle S, Ring S, Schmees N, Prien O, Schäfer M, Friedrich C, Zollner TM, Steinmeyer A, Mueller T, Langer G. Panknin O, et al. Among authors: nubbemeyer r. J Med Chem. 2020 Oct 22;63(20):11854-11881. doi: 10.1021/acs.jmedchem.0c01076. Epub 2020 Oct 6. J Med Chem. 2020. PMID: 32960053
Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo.
Wortmann L, Lindenthal B, Muhn P, Walter A, Nubbemeyer R, Heldmann D, Sobek L, Morandi F, Schrey AK, Moosmayer D, Günther J, Kuhnke J, Koppitz M, Lücking U, Röhn U, Schäfer M, Nowak-Reppel K, Kühne R, Weinmann H, Langer G. Wortmann L, et al. Among authors: nubbemeyer r. J Med Chem. 2019 Nov 27;62(22):10321-10341. doi: 10.1021/acs.jmedchem.9b01382. Epub 2019 Nov 13. J Med Chem. 2019. PMID: 31670515
Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile.
Werner S, Mesch S, Hillig RC, Ter Laak A, Klint J, Neagoe I, Laux-Biehlmann A, Dahllöf H, Bräuer N, Puetter V, Nubbemeyer R, Schulz S, Bairlein M, Zollner TM, Steinmeyer A. Werner S, et al. Among authors: nubbemeyer r. J Med Chem. 2019 Dec 26;62(24):11194-11217. doi: 10.1021/acs.jmedchem.9b01304. Epub 2019 Dec 11. J Med Chem. 2019. PMID: 31746599
Efomycine M: an inhibitor of selectins?
von Bonin A, Buchmann B, Bader B, Rausch A, Venstrom K, Schäfer M, Gründemann S, Günther J, Zorn L, Nubbemeyer R, Asadullah K, Zollner TM. von Bonin A, et al. Among authors: nubbemeyer r. Nat Med. 2006 Aug;12(8):873; author reply 873-4. doi: 10.1038/nm0806-873a. Nat Med. 2006. PMID: 16892024 No abstract available.
Estradiol release kinetics determine tissue response in ovariectomized rats.
Otto C, Kantner I, Nubbemeyer R, Schkoldow J, Fuchs I, Krahl E, Vonk R, Schüler C, Fritzemeier KH, Erben RG. Otto C, et al. Among authors: nubbemeyer r. Endocrinology. 2012 Apr;153(4):1725-33. doi: 10.1210/en.2011-1801. Epub 2012 Feb 14. Endocrinology. 2012. PMID: 22334713
Biological effects of ERalpha- and ERbeta-selective estrogens.
Fritzemeier KH, Hillisch A, Elger W, Kaufmann U, Kollenkirchen U, Kosemund D, Lindenthal B, Müller G, Muhn P, Nubbemeyer R, Peters O, Siebel P, Hegele-Hartung C. Fritzemeier KH, et al. Among authors: nubbemeyer r. Ernst Schering Res Found Workshop. 2004;(46):127-50. Ernst Schering Res Found Workshop. 2004. PMID: 15248509 Review. No abstract available.
Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839.
Bothe U, Günther J, Nubbemeyer R, Siebeneicher H, Ring S, Bömer U, Peters M, Rausch A, Denner K, Himmel H, Sutter A, Terebesi I, Lange M, Wengner AM, Guimond N, Thaler T, Platzek J, Eberspächer U, Schäfer M, Steuber H, Zollner TM, Steinmeyer A, Schmidt N. Bothe U, et al. Among authors: nubbemeyer r. J Med Chem. 2024 Jan 25;67(2):1225-1242. doi: 10.1021/acs.jmedchem.3c01714. Epub 2024 Jan 16. J Med Chem. 2024. PMID: 38228402 Free PMC article.
13 results