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JM-20 protects memory acquisition and consolidation on scopolamine model of cognitive impairment.
Wong-Guerra M, Jiménez-Martin J, Fonseca-Fonseca LA, Ramírez-Sánchez J, Montano-Peguero Y, Rocha JB, D Avila F, de Assis AM, Souza DO, Pardo-Andreu GL, Del Valle RM, Lopez GA, Martínez OV, García NM, Mondelo-Rodríguez A, Padrón-Yaquis AS, Nuñez-Figueredo Y. Wong-Guerra M, et al. Neurol Res. 2019 May;41(5):385-398. doi: 10.1080/01616412.2019.1573285. Epub 2019 Mar 1. Neurol Res. 2019. PMID: 30821663
JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
Nuñez-Figueredo Y, Ramírez-Sánchez J, Delgado-Hernández R, Porto-Verdecia M, Ochoa-Rodríguez E, Verdecia-Reyes Y, Marin-Prida J, González-Durruthy M, Uyemura SA, Rodrigues FP, Curti C, Souza DO, Pardo-Andreu GL. Nuñez-Figueredo Y, et al. Eur J Pharmacol. 2014 Mar 5;726:57-65. doi: 10.1016/j.ejphar.2014.01.021. Eur J Pharmacol. 2014. PMID: 24462350 Free article.
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.
Nuñez-Figueredo Y, Ramírez-Sánchez J, Hansel G, Simões Pires EN, Merino N, Valdes O, Delgado-Hernández R, Parra AL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Salbego C, Costa SL, Souza DO, Pardo-Andreu GL. Nuñez-Figueredo Y, et al. Neuropharmacology. 2014 Oct;85:517-27. doi: 10.1016/j.neuropharm.2014.06.009. Epub 2014 Jun 19. Neuropharmacology. 2014. PMID: 24953828
Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: mitoprotection against Ca²⁺-induced mitochondrial impairment.
Nuñez-Figueredo Y, Pardo-Andreu GL, Ramírez-Sánchez J, Delgado-Hernández R, Ochoa-Rodríguez E, Verdecia-Reyes Y, Naal Z, Muller AP, Portela LV, Souza DO. Nuñez-Figueredo Y, et al. Brain Res Bull. 2014 Oct;109:68-76. doi: 10.1016/j.brainresbull.2014.10.001. Epub 2014 Oct 13. Brain Res Bull. 2014. PMID: 25305343 Free article.
34 results