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LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes.
Della Valle F, Reddy P, Yamamoto M, Liu P, Saera-Vila A, Bensaddek D, Zhang H, Prieto Martinez J, Abassi L, Celii M, Ocampo A, Nuñez Delicado E, Mangiavacchi A, Aiese Cigliano R, Rodriguez Esteban C, Horvath S, Izpisua Belmonte JC, Orlando V. Della Valle F, et al. Among authors: nunez delicado e. Sci Transl Med. 2022 Aug 10;14(657):eabl6057. doi: 10.1126/scitranslmed.abl6057. Epub 2022 Aug 10. Sci Transl Med. 2022. PMID: 35947677
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.
Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Rodriguez Esteban C, Nuñez G, Nuñez Delicado E, Campistol JM, Guillen I, Guillen P, Izpisua Belmonte JC. Ocampo A, et al. Among authors: nunez g, nunez delicado e. Cell. 2016 Dec 15;167(7):1719-1733.e12. doi: 10.1016/j.cell.2016.11.052. Cell. 2016. PMID: 27984723 Free PMC article.
Interspecies Chimerism with Mammalian Pluripotent Stem Cells.
Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilariño M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sánchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nuñez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC. Wu J, et al. Among authors: nunez delicado e. Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036. Cell. 2017. PMID: 28129541 Free PMC article.
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.
Liao HK, Hatanaka F, Araoka T, Reddy P, Wu MZ, Sui Y, Yamauchi T, Sakurai M, O'Keefe DD, Núñez-Delicado E, Guillen P, Campistol JM, Wu CJ, Lu LF, Esteban CR, Izpisua Belmonte JC. Liao HK, et al. Among authors: nunez delicado e. Cell. 2017 Dec 14;171(7):1495-1507.e15. doi: 10.1016/j.cell.2017.10.025. Epub 2017 Dec 7. Cell. 2017. PMID: 29224783 Free PMC article.
In vivo reprogramming of wound-resident cells generates skin epithelial tissue.
Kurita M, Araoka T, Hishida T, O'Keefe DD, Takahashi Y, Sakamoto A, Sakurai M, Suzuki K, Wu J, Yamamoto M, Hernandez-Benitez R, Ocampo A, Reddy P, Shokhirev MN, Magistretti P, Núñez Delicado E, Eto H, Harii K, Izpisua Belmonte JC. Kurita M, et al. Among authors: nunez delicado e. Nature. 2018 Sep;561(7722):243-247. doi: 10.1038/s41586-018-0477-4. Epub 2018 Sep 5. Nature. 2018. PMID: 30185909 Free PMC article.
Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway.
Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Sancho-Martinez I, Takahashi Y, Hatanaka F, Wu J, Ocampo A, Reddy P, Wu MZ, Gerken L, Shaw RJ, Rodriguez Esteban C, Benner C, Nakagawa H, Guillen Garcia P, Nuñez Delicado E, Castells A, Campistol JM, Liu GH, Izpisua Belmonte JC. Hishida T, et al. Among authors: nunez delicado e. Protein Cell. 2019 Jul;10(7):485-495. doi: 10.1007/s13238-019-0630-3. Epub 2019 Apr 30. Protein Cell. 2019. PMID: 31041783 Free PMC article.
Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction.
Suzuki K, Yamamoto M, Hernandez-Benitez R, Li Z, Wei C, Soligalla RD, Aizawa E, Hatanaka F, Kurita M, Reddy P, Ocampo A, Hishida T, Sakurai M, Nemeth AN, Nuñez Delicado E, Campistol JM, Magistretti P, Guillen P, Rodriguez Esteban C, Gong J, Yuan Y, Gu Y, Liu GH, López-Otín C, Wu J, Zhang K, Izpisua Belmonte JC. Suzuki K, et al. Among authors: nunez delicado e. Cell Res. 2019 Oct;29(10):804-819. doi: 10.1038/s41422-019-0213-0. Epub 2019 Aug 23. Cell Res. 2019. PMID: 31444470 Free PMC article.
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.
Li R, Zhong C, Yu Y, Liu H, Sakurai M, Yu L, Min Z, Shi L, Wei Y, Takahashi Y, Liao HK, Qiao J, Deng H, Nuñez-Delicado E, Rodriguez Esteban C, Wu J, Izpisua Belmonte JC. Li R, et al. Among authors: nunez delicado e. Cell. 2019 Oct 17;179(3):687-702.e18. doi: 10.1016/j.cell.2019.09.029. Cell. 2019. PMID: 31626770 Free PMC article.
First progeria monkey model generated using base editor.
Reddy P, Shao Y, Hernandez-Benitez R, Nuñez Delicado E, Izpisua Belmonte JC. Reddy P, et al. Among authors: nunez delicado e. Protein Cell. 2020 Dec;11(12):862-865. doi: 10.1007/s13238-020-00765-z. Protein Cell. 2020. PMID: 32729023 Free PMC article. Review. No abstract available.
Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo.
Tan T, Wu J, Si C, Dai S, Zhang Y, Sun N, Zhang E, Shao H, Si W, Yang P, Wang H, Chen Z, Zhu R, Kang Y, Hernandez-Benitez R, Martinez Martinez L, Nuñez Delicado E, Berggren WT, Schwarz M, Ai Z, Li T, Rodriguez Esteban C, Ji W, Niu Y, Izpisua Belmonte JC. Tan T, et al. Among authors: nunez delicado e. Cell. 2021 Apr 15;184(8):2020-2032.e14. doi: 10.1016/j.cell.2021.03.020. Cell. 2021. PMID: 33861963 Free article.
69 results