Nowick JS - Search Results

1

Teixobactin kills bacteria by a two-pronged attack on the cell envelope.

Shukla R, Lavore F, Maity S, Derks MGN, Jones CR, Vermeulen BJA, Melcrová A, Morris MA, Becker LM, Wang X, Kumar R, Medeiros-Silva J, van Beekveld RAM, Bonvin AMJJ, Lorent JH, Lelli M, Nowick JS, MacGillavry HD, Peoples AJ, Spoering AL, Ling LL, Hughes DE, Roos WH, Breukink E, Lewis K, Weingarth M. Shukla R, et al. Among authors: nowick js. Nature. 2022 Aug;608(7922):390-396. doi: 10.1038/s41586-022-05019-y. Epub 2022 Aug 3. Nature. 2022. PMID: 35922513 Free PMC article.

2

Amyloid-α Peptide Formed through Alternative Processing of the Amyloid Precursor Protein Attenuates Alzheimer's Amyloid-β Toxicity via Cross-Chaperoning.

Kuhn AJ, Chan K, Sajimon M, Yoo S, Balasco Serrão VH, Lee J, Abrams B, Nowick JS, Uversky VN, Wheeler C, Raskatov JA. Kuhn AJ, et al. Among authors: nowick js. J Am Chem Soc. 2024 Jan 31;146(4):2634-2645. doi: 10.1021/jacs.3c11511. Epub 2024 Jan 18. J Am Chem Soc. 2024. PMID: 38236059

3

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity.

Cheng PN, Liu C, Zhao M, Eisenberg D, Nowick JS. Cheng PN, et al. Among authors: nowick js. Nat Chem. 2012 Nov;4(11):927-33. doi: 10.1038/nchem.1433. Epub 2012 Sep 9. Nat Chem. 2012. PMID: 23089868 Free PMC article.

4

Elucidation of the Teixobactin Pharmacophore.

Yang H, Chen KH, Nowick JS. Yang H, et al. Among authors: nowick js. ACS Chem Biol. 2016 Jul 15;11(7):1823-6. doi: 10.1021/acschembio.6b00295. Epub 2016 Jun 3. ACS Chem Biol. 2016. PMID: 27232661 Free PMC article.

5

X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.

Yang H, Du Bois DR, Ziller JW, Nowick JS. Yang H, et al. Among authors: nowick js. Chem Commun (Camb). 2017 Feb 28;53(18):2772-2775. doi: 10.1039/c7cc00783c. Chem Commun (Camb). 2017. PMID: 28217800 Free PMC article.

6

X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly.

Yang H, Wierzbicki M, Du Bois DR, Nowick JS. Yang H, et al. Among authors: nowick js. J Am Chem Soc. 2018 Oct 31;140(43):14028-14032. doi: 10.1021/jacs.8b07709. Epub 2018 Oct 12. J Am Chem Soc. 2018. PMID: 30296063 Free PMC article.

7

A Fluorescent Teixobactin Analogue.

Morris MA, Malek M, Hashemian MH, Nguyen BT, Manuse S, Lewis K, Nowick JS. Morris MA, et al. Among authors: nowick js. ACS Chem Biol. 2020 May 15;15(5):1222-1231. doi: 10.1021/acschembio.9b00908. Epub 2020 Feb 26. ACS Chem Biol. 2020. PMID: 32045203 Free PMC article.

8

Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists.

Zhang S, Krumberger M, Morris MA, Parrocha CMT, Kreutzer AG, Nowick JS. Zhang S, et al. Among authors: nowick js. Eur J Med Chem. 2021 Jun 5;218:113390. doi: 10.1016/j.ejmech.2021.113390. Epub 2021 Mar 20. Eur J Med Chem. 2021. PMID: 33812315 Free PMC article.

9

A cyclic peptide inhibitor of the SARS-CoV-2 main protease.

Kreutzer AG, Krumberger M, Diessner EM, Parrocha CMT, Morris MA, Guaglianone G, Butts CT, Nowick JS. Kreutzer AG, et al. Among authors: nowick js. Eur J Med Chem. 2021 Oct 5;221:113530. doi: 10.1016/j.ejmech.2021.113530. Epub 2021 May 5. Eur J Med Chem. 2021. PMID: 34023738 Free PMC article.

10

Visualizing Teixobactin Supramolecular Assemblies and Cell Wall Damage in B. Subtilis Using CryoEM.

Hurst PJ, Morris MA, Graham AA, Nowick JS, Patterson JP. Hurst PJ, et al. Among authors: nowick js. ACS Omega. 2021 Oct 7;6(41):27412-27417. doi: 10.1021/acsomega.1c04331. eCollection 2021 Oct 19. ACS Omega. 2021. PMID: 34693162 Free PMC article.

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