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Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
Adams GL, Pall PS, Grauer SM, Zhou X, Ballard JE, Vavrek M, Kraus RL, Morissette P, Li N, Colarusso S, Bianchi E, Palani A, Klein R, John CT, Wang D, Tudor M, Nolting AF, Biba M, Nowak T, Makarov AA, Reibarkh M, Buevich AV, Zhong W, Regalado EL, Wang X, Gao Q, Shahripour A, Zhu Y, de Simone D, Frattarelli T, Pasquini NM, Magotti P, Iaccarino R, Li Y, Solly K, Lee KJ, Wang W, Chen F, Zeng H, Wang J, Regan H, Amin RP, Regan CP, Burgey CS, Henze DA, Sun C, Tellers DM. Adams GL, et al. Among authors: nowak t. J Med Chem. 2022 Jan 13;65(1):485-496. doi: 10.1021/acs.jmedchem.1c01570. Epub 2021 Dec 21. J Med Chem. 2022. PMID: 34931831
Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances.
Haidar Ahmad IA , Chen W , Halsey HM , Klapars A , Limanto J , Pirrone GF , Nowak T , Bennett R , Hartman R , Makarov AA , Mangion I , Regalado EL . Haidar Ahmad IA , et al. Among authors: nowak t. Analyst. 2019 Apr 23;144(9):2872-2880. doi: 10.1039/c8an02499e. Analyst. 2019. PMID: 30830135
Trapping-Enrichment Multi-dimensional Liquid Chromatography with On-Line Deuterated Solvent Exchange for Streamlined Structure Elucidation at the Microgram Scale.
Ahmad IAH, Losacco GL, Shchurik V, Wang X, Cohen RD, Herron AN, Aiken S, Fiorito D, Wang H, Reibarkh M, Nowak T, Makarov AA, Stoll DR, Guillarme D, Mangion I, Aggarwal VK, Yu JQ, Regalado EL. Ahmad IAH, et al. Among authors: nowak t. Angew Chem Int Ed Engl. 2022 May 16;61(21):e202117655. doi: 10.1002/anie.202117655. Epub 2022 Feb 21. Angew Chem Int Ed Engl. 2022. PMID: 35139257
528 results