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NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells.
Muthuswamy R, Berk E, Junecko BF, Zeh HJ, Zureikat AH, Normolle D, Luong TM, Reinhart TA, Bartlett DL, Kalinski P. Muthuswamy R, et al. Among authors: normolle d. Cancer Res. 2012 Aug 1;72(15):3735-43. doi: 10.1158/0008-5472.CAN-11-4136. Epub 2012 May 16. Cancer Res. 2012. PMID: 22593190 Free PMC article.
A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients.
Zeh HJ, Bahary N, Boone BA, Singhi AD, Miller-Ocuin JL, Normolle DP, Zureikat AH, Hogg ME, Bartlett DL, Lee KK, Tsung A, Marsh JW, Murthy P, Tang D, Seiser N, Amaravadi RK, Espina V, Liotta L, Lotze MT. Zeh HJ, et al. Among authors: normolle dp. Clin Cancer Res. 2020 Jul 1;26(13):3126-3134. doi: 10.1158/1078-0432.CCR-19-4042. Epub 2020 Mar 10. Clin Cancer Res. 2020. PMID: 32156749 Free PMC article. Clinical Trial.
Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma.
Boone BA, Bahary N, Zureikat AH, Moser AJ, Normolle DP, Wu WC, Singhi AD, Bao P, Bartlett DL, Liotta LA, Espina V, Loughran P, Lotze MT, Zeh HJ 3rd. Boone BA, et al. Among authors: normolle dp. Ann Surg Oncol. 2015 Dec;22(13):4402-10. doi: 10.1245/s10434-015-4566-4. Epub 2015 Apr 24. Ann Surg Oncol. 2015. PMID: 25905586 Free PMC article. Clinical Trial.
5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers.
Van Der Kraak L, Goel G, Ramanan K, Kaltenmeier C, Zhang L, Normolle DP, Freeman GJ, Tang D, Nason KS, Davison JM, Luketich JD, Dhupar R, Lotze MT. Van Der Kraak L, et al. Among authors: normolle dp. J Immunother Cancer. 2016 Oct 18;4:65. doi: 10.1186/s40425-016-0163-8. eCollection 2016. J Immunother Cancer. 2016. PMID: 27777774 Free PMC article.
Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells.
Somasundaram A, Cillo AR, Lampenfeld C, Workman CJ, Kunning S, Oliveri L, Velez M, Joyce S, Calderon M, Dadey R, Rajasundaram D, Normolle DP, Watkins SC, Herman JG, Kirkwood JM, Lipson EJ, Ferris RL, Bruno TC, Vignali DAA. Somasundaram A, et al. Among authors: normolle dp. Cancer Immunol Res. 2022 Jul 1;10(7):885-899. doi: 10.1158/2326-6066.CIR-20-0736. Cancer Immunol Res. 2022. PMID: 35587532 Free PMC article.
173 results