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Discovery of strong inhibitory properties of a monoclonal antibody of PKA and use of the antibody and a competitive photoluminescent orthosteric probe for analysis of the protein kinase.
Biochim Biophys Acta Proteins Proteom. 2020 Aug;1868(8):140427. doi: 10.1016/j.bbapap.2020.140427. Epub 2020 Apr 10.
Biochim Biophys Acta Proteins Proteom. 2020.
PMID: 32283249
Inhibitors and fluorescent probes for protein kinase PKAcβ and its S54L mutant, identified in a patient with cortisol producing adenoma.
Nonga OE, Enkvist E, Herberg FW, Uri A.
Nonga OE, et al.
Biosci Biotechnol Biochem. 2020 Sep;84(9):1839-1845. doi: 10.1080/09168451.2020.1772038. Epub 2020 Jun 7.
Biosci Biotechnol Biochem. 2020.
PMID: 32507034
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Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family.
Nonga OE, Lavogina D, Enkvist E, Kestav K, Chaikuad A, Dixon-Clarke SE, Bullock AN, Kopanchuk S, Ivan T, Ekambaram R, Viht K, Knapp S, Uri A.
Nonga OE, et al.
Molecules. 2021 Jul 19;26(14):4353. doi: 10.3390/molecules26144353.
Molecules. 2021.
PMID: 34299628
Free PMC article.
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What is the current value of fluorescence polarization assays in small molecule screening?
Uri A, Nonga OE.
Uri A, et al. Among authors: nonga oe.
Expert Opin Drug Discov. 2020 Feb;15(2):131-133. doi: 10.1080/17460441.2020.1702966. Epub 2019 Dec 13.
Expert Opin Drug Discov. 2020.
PMID: 31833421
No abstract available.
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