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A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication.
Han H, Gracia AV, Røise JJ, Boike L, Leon K, Schulze-Gahmen U, Stentzel MR, Bajaj T, Chen D, Li IC, He M, Behrouzi K, Khodabakhshi Z, Nomura DK, Mofrad MRK, Kumar GR, Ott M, Murthy N. Han H, et al. Among authors: nomura dk. RSC Adv. 2023 Apr 4;13(16):10636-10641. doi: 10.1039/d3ra00426k. eCollection 2023 Apr 3. RSC Adv. 2023. PMID: 37025664 Free PMC article.
Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.
Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. Biering SB, et al. Among authors: nomura dk. ACS Infect Dis. 2021 Aug 13;7(8):2337-2351. doi: 10.1021/acsinfecdis.1c00017. Epub 2021 Jun 15. ACS Infect Dis. 2021. PMID: 34129317
Deubiquitinase-targeting chimeras for targeted protein stabilization.
Henning NJ, Boike L, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse MJ, Dovala D, McGregor LM, Valdez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Henning NJ, et al. Among authors: nomura dk. Nat Chem Biol. 2022 Apr;18(4):412-421. doi: 10.1038/s41589-022-00971-2. Epub 2022 Feb 24. Nat Chem Biol. 2022. PMID: 35210618 Free PMC article.
Tyrosinase-Mediated Synthesis of Nanobody-Cell Conjugates.
Maza JC, García-Almedina DM, Boike LE, Hamlish NX, Nomura DK, Francis MB. Maza JC, et al. Among authors: nomura dk. ACS Cent Sci. 2022 Jul 27;8(7):955-962. doi: 10.1021/acscentsci.1c01265. Epub 2022 Jun 22. ACS Cent Sci. 2022. PMID: 35912347 Free PMC article.
Advances in covalent drug discovery.
Boike L, Henning NJ, Nomura DK. Boike L, et al. Among authors: nomura dk. Nat Rev Drug Discov. 2022 Dec;21(12):881-898. doi: 10.1038/s41573-022-00542-z. Epub 2022 Aug 25. Nat Rev Drug Discov. 2022. PMID: 36008483 Free PMC article. Review.
Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors.
Moon P, Zammit CM, Shao Q, Dovala D, Boike L, Henning NJ, Knapp M, Spradlin JN, Ward CC, Wolleb H, Fuller D, Blake G, Murphy JP, Wang F, Lu Y, Moquin SA, Tandeske L, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Toste FD, Nomura DK. Moon P, et al. Among authors: nomura dk. Chembiochem. 2023 Jun 1;24(11):e202300116. doi: 10.1002/cbic.202300116. Epub 2023 May 3. Chembiochem. 2023. PMID: 37069799
Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.
Bajaj T, Wehri E, Suryawanshi RK, King E, Pardeshi KS, Behrouzi K, Khodabakhshi Z, Schulze-Gahmen U, Kumar GR, Mofrad MRK, Nomura DK, Ott M, Schaletzky J, Murthy N. Bajaj T, et al. Among authors: nomura dk. RSC Adv. 2023 Jun 12;13(26):17667-17677. doi: 10.1039/d3ra01915b. eCollection 2023 Jun 9. RSC Adv. 2023. PMID: 37312993 Free PMC article.
De novo Design of SARS-CoV-2 Main Protease Inhibitors.
Fischer C, Vepřek NA, Peitsinis Z, Rühmann KP, Yang C, Spradlin JN, Dovala D, Nomura DK, Zhang Y, Trauner D. Fischer C, et al. Among authors: nomura dk. Synlett. 2021 Aug;33(5):458-463. doi: 10.1055/a-1582-0243. Epub 2021 Aug 10. Synlett. 2021. PMID: 35282568 Free PMC article.
177 results