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IOA-244 is a Non-ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance.
Johnson Z, Tarantelli C, Civanelli E, Cascione L, Spriano F, Fraser A, Shah P, Nomanbhoy T, Napoli S, Rinaldi A, Niewola-Staszkowska K, Lahn M, Perrin D, Wenes M, Migliorini D, Bertoni F, van der Veen L, Di Conza G. Johnson Z, et al. Among authors: nomanbhoy t. Cancer Res Commun. 2023 Apr 14;3(4):576-591. doi: 10.1158/2767-9764.CRC-22-0477. eCollection 2023 Apr. Cancer Res Commun. 2023. PMID: 37066023 Free PMC article.
Erratum: Author Correction: High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.
Zhu W, Radadiya A, Bisson C, Wenzel S, Nordin BE, Martínez-Márquez F, Imasaki T, Sedelnikova SE, Coricello A, Baumann P, Berry AH, Nomanbhoy TK, Kozarich JW, Jin Y, Rice DW, Takagi Y, Richards NGJ. Zhu W, et al. Among authors: nomanbhoy tk. Commun Biol. 2019 Nov 22;2:438. doi: 10.1038/s42003-019-0690-1. eCollection 2019. Commun Biol. 2019. PMID: 31799439 Free PMC article.
High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.
Zhu W, Radadiya A, Bisson C, Wenzel S, Nordin BE, Martínez-Márquez F, Imasaki T, Sedelnikova SE, Coricello A, Baumann P, Berry AH, Nomanbhoy TK, Kozarich JW, Jin Y, Rice DW, Takagi Y, Richards NGJ. Zhu W, et al. Among authors: nomanbhoy tk. Commun Biol. 2019 Sep 17;2:345. doi: 10.1038/s42003-019-0587-z. eCollection 2019. Commun Biol. 2019. PMID: 31552298 Free PMC article.
Direct CDKN2 Modulation of CDK4 Alters Target Engagement of CDK4 Inhibitor Drugs.
Green JL, Okerberg ES, Sejd J, Palafox M, Monserrat L, Alemayehu S, Wu J, Sykes M, Aban A, Serra V, Nomanbhoy T. Green JL, et al. Among authors: nomanbhoy t. Mol Cancer Ther. 2019 Apr;18(4):771-779. doi: 10.1158/1535-7163.MCT-18-0755. Epub 2019 Mar 5. Mol Cancer Ther. 2019. PMID: 30837298
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NS. Olson CM, et al. Among authors: nomanbhoy t. Nat Chem Biol. 2018 Feb;14(2):163-170. doi: 10.1038/nchembio.2538. Epub 2017 Dec 18. Nat Chem Biol. 2018. PMID: 29251720 Free PMC article.
ERK5 kinase activity is dispensable for cellular immune response and proliferation.
Lin EC, Amantea CM, Nomanbhoy TK, Weissig H, Ishiyama J, Hu Y, Sidique S, Li B, Kozarich JW, Rosenblum JS. Lin EC, et al. Among authors: nomanbhoy tk. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870. doi: 10.1073/pnas.1609019113. Epub 2016 Sep 27. Proc Natl Acad Sci U S A. 2016. PMID: 27679845 Free PMC article.
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