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Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.
Jacobs RT, Plattner JJ, Nare B, Wring SA, Chen D, Freund Y, Gaukel EG, Orr MD, Perales JB, Jenks M, Noe RA, Sligar JM, Zhang YK, Bacchi CJ, Yarlett N, Don R. Jacobs RT, et al. Among authors: noe ra. Future Med Chem. 2011 Aug;3(10):1259-78. doi: 10.4155/fmc.11.80. Future Med Chem. 2011. PMID: 21859301
SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.
Perales JB, Freeman J, Bacchi CJ, Bowling T, Don R, Gaukel E, Mercer L, Moore JA 3rd, Nare B, Nguyen TM, Noe RA, Randolph R, Rewerts C, Wring SA, Yarlett N, Jacobs RT. Perales JB, et al. Among authors: noe ra. Bioorg Med Chem Lett. 2011 May 15;21(10):2816-9. doi: 10.1016/j.bmcl.2011.03.097. Epub 2011 Apr 1. Bioorg Med Chem Lett. 2011. PMID: 21507639
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
Jacobs RT, Nare B, Wring SA, Orr MD, Chen D, Sligar JM, Jenks MX, Noe RA, Bowling TS, Mercer LT, Rewerts C, Gaukel E, Owens J, Parham R, Randolph R, Beaudet B, Bacchi CJ, Yarlett N, Plattner JJ, Freund Y, Ding C, Akama T, Zhang YK, Brun R, Kaiser M, Scandale I, Don R. Jacobs RT, et al. Among authors: noe ra. PLoS Negl Trop Dis. 2011 Jun;5(6):e1151. doi: 10.1371/journal.pntd.0001151. Epub 2011 Jun 28. PLoS Negl Trop Dis. 2011. PMID: 21738803 Free PMC article.
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.
Frye SV, Haffner CD, Maloney PR, Hiner RN, Dorsey GF, Noe RA, Unwalla RJ, Batchelor KW, Bramson HN, Stuart JD, et al. Frye SV, et al. Among authors: noe ra. J Med Chem. 1995 Jul 7;38(14):2621-7. doi: 10.1021/jm00014a015. J Med Chem. 1995. PMID: 7629802
21 results