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Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases.
da Silva Cunha TT, Silva RR, Rodrigues DA, de Sena Murteira Pinheiro P, Kronenberger T, Sant'Anna CMR, Noël F, Fraga CAM. da Silva Cunha TT, et al. Among authors: noel f. Biomolecules. 2022 Aug 12;12(8):1112. doi: 10.3390/biom12081112. Biomolecules. 2022. PMID: 36009006 Free PMC article.
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.
Gomes TF, Pompeu TE, Rodrigues DA, Noël F, Menegatti R, Andrade CH, Sabino JR, Gil ES, Dalla Costa T, Betti AH, Antonio CB, Rates SM, Fraga CA, Barreiro EJ, de Oliveira V. Gomes TF, et al. Among authors: noel f. Eur J Med Chem. 2013 Apr;62:214-21. doi: 10.1016/j.ejmech.2012.08.011. Epub 2012 Aug 20. Eur J Med Chem. 2013. PMID: 23353740
Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor.
Pompeu TE, Monteiro do Monte F, Bosier B, Fraga CA, Barreiro EJ, Menegatti R, Hermans E, Noël F. Pompeu TE, et al. Among authors: noel f. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Oct 1;62:1-6. doi: 10.1016/j.pnpbp.2015.04.003. Epub 2015 Apr 17. Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID: 25891249 Free article.
A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity.
Brito AF, Braga PCCS, Moreira LKS, Silva DM, Silva DPB, Sanz G, Vaz BG, de Carvalho FS, Lião LM, Silva RR, Noël F, Neri HFS, Ghedini PC, de Carvalho MF, de S Gil E, Costa EA, Menegatti R. Brito AF, et al. Among authors: noel f. Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar;391(3):255-269. doi: 10.1007/s00210-017-1451-7. Epub 2017 Dec 19. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29260264
Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor.
Silva RR, Parreiras-E-Silva LT, Pompeu TET, Duarte DA, Fraga CAM, Barreiro EJ, Menegatti R, Costa-Neto CM, Noël F. Silva RR, et al. Among authors: noel f. Front Pharmacol. 2019 Jun 4;10:628. doi: 10.3389/fphar.2019.00628. eCollection 2019. Front Pharmacol. 2019. PMID: 31214037 Free PMC article.
Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice.
Moreira LKDS, Silva RR, da Silva DM, Mendes MAS, de Brito AF, de Carvalho FS, Sanz G, Rodrigues MF, da Silva ACG, Thomaz DV, de Oliveira V, Vaz BG, Lião LM, Valadares MC, Gil ES, Costa EA, Noël F, Menegatti R. Moreira LKDS, et al. Among authors: noel f. Behav Brain Res. 2022 Jan 24;417:113582. doi: 10.1016/j.bbr.2021.113582. Epub 2021 Sep 15. Behav Brain Res. 2022. PMID: 34536431
307 results