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Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice.
Moreira LKDS, Silva RR, da Silva DM, Mendes MAS, de Brito AF, de Carvalho FS, Sanz G, Rodrigues MF, da Silva ACG, Thomaz DV, de Oliveira V, Vaz BG, Lião LM, Valadares MC, Gil ES, Costa EA, Noël F, Menegatti R. Moreira LKDS, et al. Among authors: noel f. Behav Brain Res. 2022 Jan 24;417:113582. doi: 10.1016/j.bbr.2021.113582. Epub 2021 Sep 15. Behav Brain Res. 2022. PMID: 34536431
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.
Gomes TF, Pompeu TE, Rodrigues DA, Noël F, Menegatti R, Andrade CH, Sabino JR, Gil ES, Dalla Costa T, Betti AH, Antonio CB, Rates SM, Fraga CA, Barreiro EJ, de Oliveira V. Gomes TF, et al. Among authors: noel f. Eur J Med Chem. 2013 Apr;62:214-21. doi: 10.1016/j.ejmech.2012.08.011. Epub 2012 Aug 20. Eur J Med Chem. 2013. PMID: 23353740
Biosynthesis of human diazepam and clonazepam metabolites.
de Paula NC, Araujo Cordeiro KC, de Melo Souza PL, Nogueira DF, da Silva e Sousa DB, Costa MB, Noël F, de Oliveira V. de Paula NC, et al. Among authors: noel f. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1026-9. doi: 10.1016/j.bmcl.2015.01.025. Epub 2015 Jan 20. Bioorg Med Chem Lett. 2015. PMID: 25655722
Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor.
Pompeu TE, Monteiro do Monte F, Bosier B, Fraga CA, Barreiro EJ, Menegatti R, Hermans E, Noël F. Pompeu TE, et al. Among authors: noel f. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Oct 1;62:1-6. doi: 10.1016/j.pnpbp.2015.04.003. Epub 2015 Apr 17. Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID: 25891249 Free article.
A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity.
Brito AF, Braga PCCS, Moreira LKS, Silva DM, Silva DPB, Sanz G, Vaz BG, de Carvalho FS, Lião LM, Silva RR, Noël F, Neri HFS, Ghedini PC, de Carvalho MF, de S Gil E, Costa EA, Menegatti R. Brito AF, et al. Among authors: noel f. Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar;391(3):255-269. doi: 10.1007/s00210-017-1451-7. Epub 2017 Dec 19. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29260264
The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment.
Costa FB, Cortez AP, de Ávila RI, de Carvalho FS, Andrade WM, da Cruz AF, Reis KB, Menegatti R, Lião LM, Romeiro LAS, Noël F, Fraga CAM, Barreiro EJ, Sanz G, Rodrigues MF, Vaz BG, Valadares MC. Costa FB, et al. Among authors: noel f. Biomed Pharmacother. 2018 Jun;102:481-493. doi: 10.1016/j.biopha.2018.02.120. Epub 2018 Apr 5. Biomed Pharmacother. 2018. PMID: 29579709
306 results