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An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor.
Sci Transl Med. 2023 Jun 21;15(701):eabq7839. doi: 10.1126/scitranslmed.abq7839. Epub 2023 Jun 21.
Sci Transl Med. 2023.
PMID: 37343080
Free PMC article.
CaMKII as a Therapeutic Target in Cardiovascular Disease.
Reyes Gaido OE, Nkashama LJ, Schole KL, Wang Q, Umapathi P, Mesubi OO, Konstantinidis K, Luczak ED, Anderson ME.
Reyes Gaido OE, et al. Among authors: nkashama lj.
Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:249-272. doi: 10.1146/annurev-pharmtox-051421-111814. Epub 2022 Aug 16.
Annu Rev Pharmacol Toxicol. 2023.
PMID: 35973713
Free PMC article.
Review.
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WNK kinases sense molecular crowding and rescue cell volume via phase separation.
Boyd-Shiwarski CR, Shiwarski DJ, Griffiths SE, Beacham RT, Norrell L, Morrison DE, Wang J, Mann J, Tennant W, Anderson EN, Franks J, Calderon M, Connolly KA, Cheema MU, Weaver CJ, Nkashama LJ, Weckerly CC, Querry KE, Pandey UB, Donnelly CJ, Sun D, Rodan AR, Subramanya AR.
Boyd-Shiwarski CR, et al. Among authors: nkashama lj.
Cell. 2022 Nov 23;185(24):4488-4506.e20. doi: 10.1016/j.cell.2022.09.042. Epub 2022 Oct 31.
Cell. 2022.
PMID: 36318922
Free PMC article.
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The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice.
Porter AW, Nguyen DN, Clayton DR, Ruiz WG, Mutchler SM, Ray EC, Marciszyn AL, Nkashama LJ, Subramanya AR, Gingras S, Kleyman TR, Apodaca G, Hendershot LM, Brodsky JL, Buck TM.
Porter AW, et al. Among authors: nkashama lj.
JCI Insight. 2022 Mar 8;7(5):e151869. doi: 10.1172/jci.insight.151869.
JCI Insight. 2022.
PMID: 35104250
Free PMC article.
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L-WNK1 is required for BK channel activation in intercalated cells.
Ray EC, Carrisoza-Gaytan R, Al-Bataineh M, Marciszyn AL, Nkashama LJ, Chen J, Winfrey A, Griffiths S, Lam TR, Flores D, Wu P, Wang W, Huang CL, Subramanya AR, Kleyman TR, Satlin LM.
Ray EC, et al. Among authors: nkashama lj.
Am J Physiol Renal Physiol. 2021 Aug 1;321(2):F245-F254. doi: 10.1152/ajprenal.00472.2020. Epub 2021 Jul 6.
Am J Physiol Renal Physiol. 2021.
PMID: 34229479
Free PMC article.
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Effects of extreme potassium stress on blood pressure and renal tubular sodium transport.
Boyd-Shiwarski CR, Weaver CJ, Beacham RT, Shiwarski DJ, Connolly KA, Nkashama LJ, Mutchler SM, Griffiths SE, Knoell SA, Sebastiani RS, Ray EC, Marciszyn AL, Subramanya AR.
Boyd-Shiwarski CR, et al. Among authors: nkashama lj.
Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1341-F1356. doi: 10.1152/ajprenal.00527.2019. Epub 2020 Apr 13.
Am J Physiol Renal Physiol. 2020.
PMID: 32281415
Free PMC article.
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Intercalated cell BKα subunit is required for flow-induced K+ secretion.
Carrisoza-Gaytan R, Ray EC, Flores D, Marciszyn AL, Wu P, Liu L, Subramanya AR, Wang W, Sheng S, Nkashama LJ, Chen J, Jackson EK, Mutchler SM, Heja S, Kohan DE, Satlin LM, Kleyman TR.
Carrisoza-Gaytan R, et al. Among authors: nkashama lj.
JCI Insight. 2020 Apr 7;5(8):e130553. doi: 10.1172/jci.insight.130553.
JCI Insight. 2020.
PMID: 32255763
Free PMC article.
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Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent.
Boyd-Shiwarski CR, Shiwarski DJ, Roy A, Namboodiri HN, Nkashama LJ, Xie J, McClain KL, Marciszyn A, Kleyman TR, Tan RJ, Stolz DB, Puthenveedu MA, Huang CL, Subramanya AR.
Boyd-Shiwarski CR, et al. Among authors: nkashama lj.
Mol Biol Cell. 2018 Feb 15;29(4):499-509. doi: 10.1091/mbc.E17-08-0529. Epub 2017 Dec 13.
Mol Biol Cell. 2018.
PMID: 29237822
Free PMC article.
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