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Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.
Soyama H, Nishio M, Otani J, Sakuma T, Takao S, Hara S, Masuda T, Mimori K, Toyokuni S, Lydon JP, Nakao K, Nishina H, Fukumoto T, Maehama T, Suzuki A. Soyama H, et al. Among authors: nishina h. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2123134119. doi: 10.1073/pnas.2123134119. Epub 2022 Jul 11. Proc Natl Acad Sci U S A. 2022. PMID: 35858357 Free PMC article.
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.
Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-Ya K, Mimori K, Suzuki A. Nishio M, et al. Among authors: nishina h. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E71-80. doi: 10.1073/pnas.1517188113. Epub 2015 Dec 22. Proc Natl Acad Sci U S A. 2016. PMID: 26699479 Free PMC article.
Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency.
Nishio M, Miyachi Y, Otani J, Tane S, Omori H, Ueda F, Togashi H, Sasaki T, Mak TW, Nakao K, Fujita Y, Nishina H, Maehama T, Suzuki A. Nishio M, et al. Among authors: nishina h. FASEB J. 2019 Apr;33(4):5548-5560. doi: 10.1096/fj.201802005R. Epub 2019 Jan 14. FASEB J. 2019. PMID: 30640535
Our data show that YAP1 activation controls cell competition in part by decreasing cell adhesion.-Nishio, M., Miyachi, Y., Otani, J., Tane, S., Omori, H., Ueda, F., Togashi, H., Sasaki, T., Mak, T. W., Nakao, K., Fujita, Y., Nishina, H., Maehama, T., S …
Our data show that YAP1 activation controls cell competition in part by decreasing cell adhesion.-Nishio, M., Miyachi, Y., Otani, J., Tane, …
YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.
Omori H, Nishio M, Masuda M, Miyachi Y, Ueda F, Nakano T, Sato K, Mimori K, Taguchi K, Hikasa H, Nishina H, Tashiro H, Kiyono T, Mak TW, Nakao K, Nakagawa T, Maehama T, Suzuki A. Omori H, et al. Among authors: nishina h. Sci Adv. 2020 Mar 18;6(12):eaay3324. doi: 10.1126/sciadv.aay3324. eCollection 2020 Mar. Sci Adv. 2020. PMID: 32206709 Free PMC article.
Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.
Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Wah Mak T, Kiyono T, Katabuchi H, Tashiro H, Suzuki A. Nishio M, et al. Among authors: nishina h. Cancer Sci. 2020 Oct;111(10):3576-3587. doi: 10.1111/cas.14581. Epub 2020 Aug 21. Cancer Sci. 2020. PMID: 32716083 Free PMC article.
Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.
Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A. Nakatani K, et al. Among authors: nishina h. Cancer Sci. 2021 Oct;112(10):4303-4316. doi: 10.1111/cas.15079. Epub 2021 Aug 6. Cancer Sci. 2021. PMID: 34289205 Free PMC article.
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki SO, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki A. Nishio M, et al. Among authors: nishina h. J Clin Invest. 2012 Dec;122(12):4505-18. doi: 10.1172/JCI63735. Epub 2012 Nov 12. J Clin Invest. 2012. PMID: 23143302 Free PMC article.
YAP determines the cell fate of injured mouse hepatocytes in vivo.
Miyamura N, Hata S, Itoh T, Tanaka M, Nishio M, Itoh M, Ogawa Y, Terai S, Sakaida I, Suzuki A, Miyajima A, Nishina H. Miyamura N, et al. Among authors: nishina h. Nat Commun. 2017 Jul 6;8:16017. doi: 10.1038/ncomms16017. Nat Commun. 2017. PMID: 28681838 Free PMC article.
306 results